Evidence map›Paper›PMID 32549254›Full record

ArticleInternational journal of molecular sciences2020

A Synthetic Cell-Penetrating Heparin-Binding Peptide Derived from BMP4 with Anti-Inflammatory and Chondrogenic Functions for the Treatment of Arthritis.

Da Hyeon Choi, Dongwoo Lee, Beom Soo Jo, Kwang-Sook Park, Kyeong Eun Lee, Ju Kwang Choi, Yoon Jeong Park, Jue-Yeon Lee, Yoon Shin Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Da Hyeon ChoiSchool of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Korea.
Dongwoo LeeCentral Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), School of Dentistry, Seoul National University, Seoul 03080, Korea.
Beom Soo JoCentral Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), School of Dentistry, Seoul National University, Seoul 03080, Korea.
Kwang-Sook ParkDepartment of Dental Regenerative Bioengineering and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea.
Kyeong Eun LeeSchool of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Korea.
Ju Kwang ChoiSchool of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Korea.
Yoon Jeong ParkCentral Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), School of Dentistry, Seoul National University, Seoul 03080, Korea.
Jue-Yeon LeeCentral Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC), School of Dentistry, Seoul National University, Seoul 03080, Korea.
Yoon Shin ParkSchool of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Korea.
Seoul National University · KRChungbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report dual therapeutic effects of a synthetic heparin-binding peptide (HBP) corresponding to residues 15-24 of the heparin binding site in BMP4 in a collagen-induced rheumatic arthritis model (CIA) for the first time. The cell penetrating capacity of HBP led to improved cartilage recovery and anti-inflammatory effects via down-regulation of the iNOS-IFN

Indexed as

AnimalsAnti-Inflammatory AgentsArthritis, ExperimentalArthritis, RheumatoidBinding SitesBone Morphogenetic Protein 4Cell-Penetrating PeptidesCells, CulturedChondrocytesCytokinesDisease Models, AnimalDrug SynergismEtanerceptGene Expression RegulationHeparinHumansAnti-Inflammatory AgentsBMP4 protein, humanBone Morphogenetic Protein 4Cell-Penetrating PeptidesCytokinesEtanerceptHeparinLipopolysaccharidesanti-inflammatory peptidecell permeable peptidecollagen-induced arthritisEnbrelheparin-binding peptideinducible nitric oxideinterferon gammainterleukin-6

Identifiers

PMID32549254
PMCPMC7352680
OpenAlexW3034915717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.