Evidence map›Paper›PMID 32549196›Full record

Trial reportToxins2020

Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial.

Giancarlo De la Torre Canales, Natalia Alvarez-Pinzon, Victor Ricardo Manuel Muñoz-Lora, Leonardo Vieira Peroni, Amanda Farias Gomes, Alfonso Sánchez-Ayala, Francisco Haiter-Neto, Daniele Manfredini, Célia Marisa Rizzatti-Barbosa

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05720065 (Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A. A Randomized, Controlled, Double-blind Study), which is not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05720065 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A. A Randomized, Controlled, Double-blind Study

TypeinterventionalSponsorKarolinska InstitutetRan2023 to 2027Enrolled100ConditionsTemporomandibular DisordersArmsBotulinum toxin type A, Isotonic saline 0,9%
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Giancarlo De la Torre CanalesDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Sao Paulo 13414-903, Brazil.ORCID 0000-0002-0921-342X
Natalia Alvarez-PinzonDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Sao Paulo 13414-903, Brazil.
Victor Ricardo Manuel Muñoz-LoraDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Sao Paulo 13414-903, Brazil.ORCID 0000-0002-1134-8542
Leonardo Vieira PeroniDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Sao Paulo 13414-903, Brazil.ORCID 0000-0002-1391-6216
Amanda Farias GomesDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Sao Paulo 13414-903, Brazil.ORCID 0000-0002-4707-4838
Alfonso Sánchez-AyalaDepartment of Dentistry, State University of Ponta Grossa, Paraná 84030-900, Brazil.ORCID 0000-0003-3426-0997
Francisco Haiter-NetoDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Sao Paulo 13414-903, Brazil.
Daniele ManfrediniDepartment of Dentistry, University of Siena, 53100 Siena, Italy.
Célia Marisa Rizzatti-BarbosaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Sao Paulo 13414-903, Brazil.ORCID 0000-0003-1709-2987
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Estadual de Ponta Grossa · BRUniversity of Siena · IT

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/15863-7
6 · The paper itself

Abstract

This study assessed the safety and efficacy of three different doses of BoNT-A for persistent myofascial pain (MFP). One hundred female subjects were randomly assigned into five groups (

Indexed as

AdultAnalgesicsBotulinum Toxins, Type ABrazilDose-Response Relationship, DrugFacial PainFemaleHumansMasticationPain MeasurementPain ThresholdTime FactorsTreatment OutcomeAnalgesicsBotulinum Toxins, Type Abone lossbotulinum toxin type Achronic painmyofascial paintemporomandibular disorders

Identifiers

PMID32549196
PMCPMC7354430
OpenAlexW3036313932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.