Evidence map›Paper›PMID 32548952›Full record

ArticleJournal of cellular and molecular medicine2020

Asiaticoside might attenuate bleomycin-induced pulmonary fibrosis by activating cAMP and Rap1 signalling pathway assisted by A2AR.

Jing Luo, Ting Zhang, Chengwei Zhu, Junwei Sun, Wenjing Zhu, Wenxiu Ai, Xiaoying Huang, Xiaobing Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 46 citations in OpenAlex.

  1. Therapeutic potential ofPharmaceutical biology · 2026
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  12. The effect of extracorporeal shock wave on joint capsule fibrosis based on AJournal of orthopaedic surgery and research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jing LuoDepartment of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ting ZhangDepartment of Pulmonary and Critical Care Medicine, The First People's Hospital of Wenling, Zhenjiang, China.
Chengwei ZhuDepartment of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Junwei SunDivision of Pulmonary Medicine, First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, China.
Wenjing ZhuDivision of Pulmonary Medicine, First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, China.
Wenxiu AiDivision of Pulmonary Medicine, First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, China.
Xiaoying HuangDivision of Pulmonary Medicine, First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, China.
Xiaobing WangDepartment of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-4302-2213
Wenzhou Medical University · CNThe First People's Hospital of Wenling · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asiaticoside (AS) has been reported to have protective effect on pulmonary fibrosis (PF). In this study, we aimed to explore the potential mechanism of the therapeutic role of AS and its relationship with A2AR in PF. Adenosine 2A receptor gene knockout (A2AR

Indexed as

AnimalsBleomycinComputational BiologyCyclic AMPDisease Models, AnimalGene Expression ProfilingImmunohistochemistryImmunomodulationMaleMiceMice, TransgenicModels, BiologicalProtective AgentsPulmonary Fibrosisrap1 GTP-Binding ProteinsReceptor, Adenosine A2AasiaticosideBleomycinCyclic AMPProtective Agentsrap1 GTP-Binding ProteinsReceptor, Adenosine A2ATriterpenesadenosine A2A receptoradenylate cyclaseasiaticosidecAMP and Rap1 signalling pathwaypulmonary fibrosis

Identifiers

PMID32548952
PMCPMC7348182
OpenAlexW3034522543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.