Evidence map›Paper›PMID 32548805›Full record

ReviewReproductive sciences (Thousand Oaks, Calif.)2020

Regulation of Uterine Spiral Artery Remodeling: a Review.

Eugene D Albrecht, Gerald J Pepe

Open access · hybridAbstract readReview
In one paragraph

Review in Reproductive sciences (Thousand Oaks, Calif.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. MBD1-Mediated SDHD Methylation Aggravates Preeclampsia Progression via Triggering Mitochondrial Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  6. Article
  7. Predictive Factors for Small Head Circumference Among Pregnant Women with Third-Trimester Anemia.International journal of environmental research and public health · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Insights into the maternal-fetal interface from spatial multi-omics.Frontiers in cell and developmental biology · 2026
    Review
  19. Article
  20. Update on endogenous retroviruses in cattle placenta.The Journal of reproduction and development · 2026
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Eugene D AlbrechtBressler Research Laboratories, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 655 West Baltimore St., Baltimore, MD, USA. ealbrecht@som.umaryland.edu.ORCID 0000-0003-2827-9739
Gerald J PepeDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, USA.
Eastern Virginia Medical School · USUniversity of Maryland, Baltimore · US

Funding

VEGF Gene Delivery In The Primate To Prevent Defective Spiral Artery Remodeling And Maternal Vascular DysfunctionR01HD093070 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI Graham W Aberdeen · 2017 to 2026
$5.1M
Contrast-Enhanced/Microbubble and B-Flow/M-Mode Ultrasonography to Quantify Uteroplacental Perfusion During Baboon and HumanPreganancyR01HD093946 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI TURAN, OZHAN MEHMET · 2018 to 2022
$2.6M
NICHD NIH HHS R01 HD093070NICHD NIH HHS R01 HD093946NIH HHS R01 HD 93070NIH HHS R01 HD 93946
6 · The paper itself

Abstract

Extravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting blood flow to the placenta and fetal development, but little is known about the regulation of this process. A defect in spiral artery remodeling underpins adverse conditions of human pregnancy, notably early-onset preeclampsia and fetal growth restriction, which result in maternal and fetal morbidity and mortality. Many in vitro studies have been conducted to determine the ability of growth and other factors to stimulate trophoblast cells to migrate across a synthetic membrane. Clinical studies have investigated whether the maternal levels of various factors are altered during abnormal human pregnancy. Animal models have been established to assess the ability of various factors to recapitulate the pathophysiological symptoms of preeclampsia. This review analyzes the results of the in vitro, clinical, and animal studies and describes a nonhuman primate experimental paradigm of defective uterine artery remodeling to study the regulation of vessel remodeling.

Indexed as

AnimalsFemaleHumansPlacentaPre-EclampsiaPregnancyUterine ArteryUterusVascular RemodelingAnimal modelsPreeclampsiaUterine artery remodeling

Identifiers

PMID32548805
PMCPMC7452941
OpenAlexW3034501513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.