Evidence map›Paper›PMID 32548788›Full record

ReviewCurrent allergy and asthma reports2020

Role of the Microbiome in Allergic Disease Development.

Andrea C Aguilera, Isabelle A Dagher, Kirsten M Kloepfer

Open access · greenAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
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  3. Microbiome dysbiosis and therapeutic restoration in atopic dermatitis.Frontiers in cellular and infection microbiology · 2026
    Review
  4. Article
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  6. Review
  7. Research advance in correlation between childhood asthma and gut microbiota.Frontiers in cellular and infection microbiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Andrea C AguileraDepartment of Pediatrics, Indiana School of Medicine, 705 Riley Hospital Drive, RI 2606, Indianapolis, IN, 46202, USA.
Isabelle A DagherIndiana University School of Medicine, 705 Riley Hospital Drive, RI 2606, Indianapolis, IN, 46202, USA.
Kirsten M KloepferDepartment of Pediatrics, Indiana School of Medicine, 705 Riley Hospital Drive, RI 2606, Indianapolis, IN, 46202, USA. kloepfer@iu.edu.ORCID 0000-0003-1504-8114
Riley Hospital for Children · USIndiana University Hospital · US

Funding

Upper Airway Microbial Development During the First Year of LifeK23AI135094 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KLOEPFER, KIRSTEN M · 2018 to 2022
$915k
NIAID NIH HHS K23 AI135094NIAID NIH HHS L40 AI096442
6 · The paper itself

Abstract

purpose of reviewEvidence suggests that the microbiome of the skin, gastrointestinal tract, and airway contribute to health and disease. As we learn more about the role that the microbiota plays in allergic disease development, we can develop therapeutics to alter this pathway. RECENT

findingsEpidemiologic studies reveal that an association exists between environmental exposures, which alter the microbiota, and developing atopic dermatitis, food allergy, and/or asthma. In fact, samples from the skin, gastrointestinal tract, and respiratory tract reveal distinct microbiotas compared with healthy controls, with microbial changes (dysbiosis) often preceding the development of allergic disease. Mechanistic studies have confirmed that microbes can either promote skin, gut, and airway health by strengthening barrier integrity, or they can alter skin integrity and damage gut and airway epithelium. In this review, we will discuss recent studies that reveal the link between the microbiota and immune development, and we will discuss ways to influence these changes.

Indexed as

Dermatitis, AtopicFood HypersensitivityHumansHypersensitivityMicrobiotaAsthmaAtopic dermatitisFood allergyImmune developmentMicrobiome

Identifiers

PMID32548788
PMCPMC7702839
OpenAlexW3034991098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.