Evidence map›Paper›PMID 32548649›Full record

ReviewCurrent allergy and asthma reports2020

Management of Severe Asthma Beyond the Guidelines.

Anne E Reihman, Fernando Holguin, Sunita Sharma

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Mucins and Their Roles in Asthma.Immunological reviews · 2025
    Review
  4. Emerging cell and molecular targets for treating mucus hypersecretion in asthma.Allergology international : official journal of the Japanese Society of Allergology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anne E ReihmanDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Mail Stop C272, 12700 E. 19th Avenue, Aurora, CO, 80045, USA.
Fernando HolguinDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Mail Stop C272, 12700 E. 19th Avenue, Aurora, CO, 80045, USA.
Sunita SharmaDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Mail Stop C272, 12700 E. 19th Avenue, Aurora, CO, 80045, USA. sunita.sharma@cuanschutz.edu.
University of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewAsthma is one of the most common chronic respiratory diseases worldwide, yet only a small percentage of patients are categorized as having severe disease. Severe asthmatics, however, are responsible for the largest burden of healthcare costs and lost productivity. Several recent guidelines have addressed disease pathogenesis and treatment modalities for these complex patients. Herein, we review the severe asthma guidelines, compare the existing guidelines, address key areas that are yet to be addressed in the guidelines, and discuss future directions for severe asthma research. RECENT

findingsThis is a narrative review of the 2019 European Respiratory Society/American Thoracic Society (ERS/ATS) and Global Initiative for Asthma (GINA) guidelines that specifically address the diagnosis and management of severe asthma. The pathophysiological mechanisms that underlie severe asthma are reviewed, and novel therapies that target specific pathophysiological pathways in severe asthma are discussed in detail. Although the guidelines address the use of novel biological therapies for patients with T2-mediated disease, data comparing these agents remain sparse. This review addresses several areas that are topics beyond the guidelines and highlight key areas where future research is warranted. This review provides a comprehensive overview of the current state of severe asthma treatment and discusses potential avenues for future research for this patient population.

Indexed as

AsthmaGuidelines as TopicHumansAsthmaEndotypeGuidelinesSevere asthmaTreatment

Identifiers

PMID32548649
OpenAlexW3035425309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.