ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Asymptomatic SARS-CoV-2 Infection and COVID-19 Mortality During an Outbreak Investigation in a Skilled Nursing Facility.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 9 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 9 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Effective infection prevention and control measures in long-term care facilities in non-outbreak and outbreak settings: a systematic literature review.Antimicrobial resistance and infection control · 2023Pooled it
- Clinical expressions, characteristics and treatments of confirmed COVID-19 in nursing home residents: a systematic review.BMC geriatrics · 2023Pooled it
- Meta-analysis of COVID-19 prevalence during preoperative COVID-19 screening in asymptomatic patients.BMJ open · 2022Pooled it
- Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis.PLoS medicine · 2022Pooled it
- Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals With Confirmed COVID-19 Diagnosis: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- A rapid systematic review of measures to protect older people in long-term care facilities from COVID-19.BMJ open · 2021Pooled it
- Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021Pooled it
- The Proportion of SARS-CoV-2 Infections That Are Asymptomatic : A Systematic Review.Annals of internal medicine · 2021Pooled it
- Pooled it
- Changing socioeconomic inequalities in the incidence and case fatality rates of COVID-19 in Germany, March 2020 through May 2022: an ecological study.BMC public health · 2025Article
- Post-exposure testing at healthcare facilities with SARS-CoV-2 transmission: A rapid review.Journal of public health in Africa · 2025Review
- [Brote de la COVID-19 en una residencia en ancianos correctamente vacunados. Influencia de la inmunidad híbrida en la carga viral, el riesgo de infección y el riesgo de progresión de la enfermedad].Revista espanola de salud publica · 2024Article
- Enhancing SARS-CoV-2 surveillance in Malawi using telephone syndromic surveillance from July 2020 to April 2022.BMJ global health · 2024Article
- Comparison of clinical outcomes over time of inpatients with healthcare-associated or community-acquired coronavirus disease 2019 (COVID-19): A multicenter, prospective cohort study.Infection control and hospital epidemiology · 2024Observational
- Outbreak investigation in a COVID-19 designated hospital: The combination of phylogenetic analysis and field epidemiology study suggesting airborne transmission.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2023Article
- Long-Term Care Research in the Context of COVID-19 Pandemic: A Bibliometric Analysis.Healthcare (Basel, Switzerland) · 2023Review
- A Molecular and Epidemiological Investigation of a Large SARS-CoV-2 Outbreak in a Long-Term Care Facility in Luxembourg, 2021.Geriatrics (Basel, Switzerland) · 2023Article
- Severe acute respiratory syndrome coronavirus 2 seroprevalence among patients with pulmonary tuberculosis.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Article
- Health impact of the first and second wave of COVID-19 and related restrictive measures among nursing home residents: a scoping review.BMC health services research · 2022Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOutbreaks of coronavirus disease 2019 (COVID-19) have been reported in nursing homes and assisted living facilities; however, the extent of asymptomatic and presymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in this high-risk population remains unclear.
methodsWe conducted an investigation of the first known outbreak of SARS-CoV-2 at a skilled nursing facility (SNF) in Illinois on 15 March 2020 and followed residents for 30 days. We tested 126/127 residents for SARS-CoV-2 via reverse-transcription polymerase chain reaction and performed symptom assessments. We calculated the point prevalence of SARS-CoV-2 and assessed symptom onset over 30-day follow-up to determine: (1) the proportion of cases who were symptomatic, presymptomatic, and asymptomatic and (2) incidence of symptoms among those who tested negative. We used the Kaplan-Meier method to determine the 30-day probability of death for cases.
resultsOf 126 residents tested, 33 had confirmed SARS-CoV-2 on 15 March. Nineteen (58%) had symptoms at the time of testing, 1 (3%) developed symptoms over follow-up, and 13 (39%) remained asymptomatic. Thirty-five residents who tested negative on 15 March developed symptoms over follow-up; of these, 3 were re-tested and 2 were positive. The 30-day probability of death among cases was 29%.
conclusionsSNFs are particularly vulnerable to SARS-CoV-2, and residents are at risk of severe outcomes. Attention must be paid to preventing outbreaks in these and other congregate care settings. Widespread testing and infection control are key to help prevent COVID-19 morbidity and mortality in these high-risk populations.
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