Evidence map›Paper›PMID 32548443›Full record

ArticleACS omega2020

Mass Spectrometric Imaging of the Brain Demonstrates the Regional Displacement of 6-Monoacetylmorphine by Naloxone.

Belin G Teklezgi, Annapurna Pamreddy, Sphamandla Ntshangase, Sipho Mdanda, Sanil D Singh, Nirmala D Gopal, Tricia Naicker, Hendrik G Kruger, Thavendran Govender, Sooraj Baijnath

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Belin G TeklezgiCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa.
Annapurna PamreddyCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa.
Sphamandla NtshangaseCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa.
Sipho MdandaCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa.
Sanil D SinghDepartment of Pharmaceutical Science, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa.
Nirmala D GopalDepartment of Criminology, University of KwaZulu-Natal, Durban 4041, South Africa.
Tricia NaickerCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa.
Hendrik G KrugerCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa.
Thavendran GovenderDepartment of Chemistry, University of Zululand, Richards Bay 3900, South Africa.
Sooraj BaijnathCatalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa.
University of KwaZulu-Natal · ZAUniversity of Zululand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overdose is the main cause of mortality among heroin users. Many of these overdose-induced deaths can be prevented through the timely administration of naloxone (NLX), a nonselective mu (μ)-, kappa (κ)-, and delta (δ)-opioid receptor antagonist. NLX competitively inhibits opioid-overdose-induced respiratory depression without eliciting any narcotic effect itself. The aim of this study was to investigate the antagonistic action of NLX by comparing its distribution to that of 6-monacetylmorphine (6-MAM), heroin's major metabolite, in a rodent model using mass spectrometric imaging (MSI) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Male Sprague-Dawley rats (

Identifiers

PMID32548443
PMCPMC7288357
OpenAlexW3030853041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.