ReviewACS omega2020
Nanocarriers as Potential Drug Delivery Candidates for Overcoming the Blood-Brain Barrier: Challenges and Possibilities.
Abstract readReview
In one paragraph
Review in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ferroptosis-Based Nanotherapeutic Strategies to Overcome Temozolomide Resistance in Glioblastoma: A Systematic Review and Meta-Analysis.Current oncology (Toronto, Ont.) · 2026Pooled it
- Bridging the Gap: Harnessing Phytochemical-Loaded Nanocarriers for Enhanced Epilepsy Treatment.Molecular neurobiology · 2026Review
- Blood‒brain barrier permeability assessment: from biomimetic models to multimodal imaging.Journal of Zhejiang University. Science. B · 2026Review
- Molecular neurobiological insights on integrative role of Trk neurotrophic receptors and their small-molecule agonists in neurodegenerative conditions.Experimental brain research · 2026Review
- Article
- Recent advances towards BACE1 drug discovery and therapeutics design.RSC medicinal chemistry · 2026Review
- Article
- A Microfluidic Framework for Neuroprotective Compound Triage Across Ischemia and Neurodegeneration.Molecules (Basel, Switzerland) · 2026Review
- Recent Advances in Nanoparticle-Based Drug Delivery Strategies to Cross the Blood-Brain Barrier in Targeted Treatment of Alzheimer's Disease.Pharmaceutics · 2026Review
- Utilizing nanotechnology to diagnose and treat central nervous system disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Glial Cell Dynamics in Neuroinflammation: Mechanisms, Interactions, and Therapeutic Implications.Biomedicines · 2026Review
- An integrative neuropharmacological review of Huntington's disease challenges and the role of novel formulations in addressing pharmacological‒pharmaceutical limitations.Frontiers in pharmacology · 2026Review
- Physicochemical design of nanobiomaterials in oncology: structure-to-function principles for sequential transport and delivery.Frontiers in oncology · 2026Review
- Neurogenesis and neuroplasticity activities of natural products: therapeutic potential in Alzheimer's disease.Frontiers in pharmacology · 2026Review
- Lipid and polymeric nanocarriers for siRNA delivery to the brain.Journal of controlled release : official journal of the Controlled Release Society · 2025Review
- Exploring Dopamine Neurotransmitter and Silver Nanocluster (AgACS omega · 2025Article
- Drug-Dependent Enhancement of Blood-Brain Barrier Permeation by Polysorbate 80 Minor Components.Pharmaceutics · 2025Article
- Systemic administration of gold nanoparticles attenuates anxiety-related behaviors and enhances spatial learning performance in rats.IBRO neuroscience reports · 2025Article
- Recent advances in potential drug nanocarriers for CNS disorders: a review.Biomedical engineering online · 2025Review
- Insights into the Versatile Role of Extracellular Vesicles in the Treatment of CNS Disorders.Molecular neurobiology · 2025Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Jyoti AhlawatDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Gileydis Guillama BarrosoDepartment of Chemistry, The University of Havana, Havana, Cuba.
Shima Masoudi AsilDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Melinda AlvaradoDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Isabela ArmendarizDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Jose BernalDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Ximena CarabazaDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Stephanie ChavezDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Paulina CruzDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Vassti EscalanteDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Savana EstorgaDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Daniel FernandezDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Carolina LozanoDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Martin MarrufoDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Nabeel AhmadSchool of Biotechnology, IFTM University, Moradabad, India.
Sergio NegreteDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Karyme OlveraDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Ximena ParadaDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Brianna PortilloDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Andrea RamirezDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Raul RamosDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Veronica RodriguezDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Paola RojasDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Jessica RomeroDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
David SuarezDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Graciela UruetaDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Stephanie VielDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Mahesh NarayanDepartment of Chemistry and Biochemistry, Department of Environmental Science and Engineering, and FYRIS Laboratory, Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas 79968, United States.
Funding
Phase II of BUILDing SCHOLARSUL1GM118970 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI ALEY, STEPHEN B, BOLAND, THOMAS · 2015 to 2023
$17.9MPhase II of BUILDing SCHOLARS - Student Training CoreTL4GM118971 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI ALEY, STEPHEN B, BOLAND, THOMAS · 2015 to 2023
$9.9MPhase II of BUILDing SCHOLARS - Research Enrichment CoreRL5GM118969 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI ALEY, STEPHEN B, BOLAND, THOMAS · 2015 to 2023
$7.4MNIGMS NIH HHS RL5 GM118969NIGMS NIH HHS TL4 GM118971NIGMS NIH HHS UL1 GM118970
Abstract
The design of a drug that successfully overcomes the constraints imposed by the blood-brain barrier (BBB, which acts as a gatekeeper to the entry of substances into the brain) requires an understanding of the biological firewall. It is also of utmost importance to understand the physicochemical properties of the said drug and how it engages the BBB to avoid undesired side effects. Since fewer than 5% of the tested molecules can pass through the BBB, drug development pertaining to brain-related disorders takes inordinately long to develop. Furthermore, in most cases it is also unsuccessful for allied reasons. Several drug delivery systems (DDSs) have shown excellent potential in drug delivery across the BBB while demonstrating minimal side effects. This mini-review summarizes key features of the BBB, recapitulates recent advances in our understanding of the BBB, and highlights existing strategies for the delivery of drug to the brain parenchyma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.