Evidence map›Paper›PMID 32548337›Full record

ArticleNeurobiology of pain (Cambridge, Mass.)

Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model.

Daniela Baptista-de-Souza, Diana Tavares-Ferreira, Salim Megat, Ishwarya Sankaranarayanan, Stephanie Shiers, Christopher M Flores, Sourav Ghosh, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza, Theodore J Price

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of pain (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. [Temporal changes of chronic postsurgical pain in mice: the regulatory role of CX3CL1 in the dorsal root ganglion].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  2. Article
  3. Sex differences in the transition to chronic pain.The Journal of clinical investigation · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations.Canadian journal of pain = Revue canadienne de la douleur · 2022
    Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Daniela Baptista-de-SouzaDept. Psychology, Federal University of Sao Carlos-UFSCar, Sao Carlos, SP 13565-905, Brazil.
Diana Tavares-FerreiraUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
Salim MegatUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
Ishwarya SankaranarayananUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
Stephanie ShiersUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
Christopher M FloresJanssen Research & Development, Neuroscience Therapeutic Area, San Diego, CA, United States.
Sourav GhoshYale University School of Medicine, Department of Neurology, United States.
Ricardo Luiz Nunes-de-SouzaJoint Graduate Program in Physiological Sciences UFSCar/UNESP, São Carlos, SP 13565-905, Brazil.
Azair Canto-de-SouzaDept. Psychology, Federal University of Sao Carlos-UFSCar, Sao Carlos, SP 13565-905, Brazil.
Theodore J PriceUniversity of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies, United States.
The University of Texas at Dallas · USUniversidade Estadual Paulista (Unesp) · BRJanssen (United States) · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Though sex differences in chronic pain have been consistently described in the literature, their underlying neural mechanisms are poorly understood. Previous work in humans has demonstrated that men and women differentially invoke distinct brain regions and circuits in coping with subjective pain unpleasantness. The goal of the present work was to elucidate the molecular mechanisms in the basolateral nucleus of the amygdala (BLA) that modulate hyperalgesic priming, a pain plasticity model, in males and females. We used plantar incision as the first, priming stimulus and prostaglandin E

Indexed as

aPKCBasolateral amygdalaGluA2Hyperalgesic primingSex differencesZIP

Identifiers

PMID32548337
PMCPMC7284072
OpenAlexW3033490148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.