Evidence map›Paper›PMID 32548295›Full record

ArticleTomography (Ann Arbor, Mich.)2020

A Fully Automated Deep Learning Network for Brain Tumor Segmentation.

Chandan Ganesh Bangalore Yogananda, Bhavya R Shah, Maryam Vejdani-Jahromi, Sahil S Nalawade, Gowtham K Murugesan, Frank F Yu, Marco C Pinho, Benjamin C Wagner, Kyrre E Emblem, Atle Bjørnerud and 3 more

Abstract read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Fast Submillimeter Whole-Brain TMagnetic resonance in medicine · 2026
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  12. A Self-Configuring Deep Learning Network for Segmentation of Temporal Bone Anatomy in Cone-Beam CT Imaging.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2023
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chandan Ganesh Bangalore YoganandaDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Bhavya R ShahDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Maryam Vejdani-JahromiDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Sahil S NalawadeDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Gowtham K MurugesanDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Frank F YuDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Marco C PinhoDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Benjamin C WagnerDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Kyrre E EmblemDepartment of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Atle BjørnerudComputational Radiology and Artificial Intelligence (CRAI), Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; and.
Baowei FeiDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX.
Ananth J MadhuranthakamDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.
Joseph A MaldjianDepartment of Radiology, Advanced Neuroscience Imaging Research Lab (ANSIR Lab), University of Texas Southwestern Medical Center, Dallas, TX.

Funding

Quantitative Non-Contrast Perfusion using Arterial Spin Labeling for Assessment of Cancer Therapy ResponseU01CA207091 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MADHURANTHAKAM, ANANTH J, MALDJIAN, JOSEPH A · 2017 to 2022
$3.1M
NCI NIH HHS U01 CA207091
6 · The paper itself

Abstract

We developed a fully automated method for brain tumor segmentation using deep learning; 285 brain tumor cases with multiparametric magnetic resonance images from the BraTS2018 data set were used. We designed 3 separate 3D-Dense-UNets to simplify the complex multiclass segmentation problem into individual binary-segmentation problems for each subcomponent. We implemented a 3-fold cross-validation to generalize the network's performance. The mean cross-validation Dice-scores for whole tumor (WT), tumor core (TC), and enhancing tumor (ET) segmentations were 0.92, 0.84, and 0.80, respectively. We then retrained the individual binary-segmentation networks using 265 of the 285 cases, with 20 cases held-out for testing. We also tested the network on 46 cases from the BraTS2017 validation data set, 66 cases from the BraTS2018 validation data set, and 52 cases from an independent clinical data set. The average Dice-scores for WT, TC, and ET were 0.90, 0.84, and 0.80, respectively, on the 20 held-out testing cases. The average Dice-scores for WT, TC, and ET on the BraTS2017 validation data set, the BraTS2018 validation data set, and the clinical data set were as follows: 0.90, 0.80, and 0.78; 0.90, 0.82, and 0.80; and 0.85, 0.80, and 0.77, respectively. A fully automated deep learning method was developed to segment brain tumors into their subcomponents, which achieved high prediction accuracy on the BraTS data set and on the independent clinical data set. This method is promising for implementation into a clinical workflow.

Indexed as

Brain NeoplasmsDeep LearningHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNeural Networks, ComputerBrain tumor segmentationBraTSCNN (convolutional neural networks)deep learningDense UNetmachine learningMRI

Identifiers

PMID32548295
PMCPMC7289260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.