ArticleWorld journal of clinical cases2020
Clinical prediction of complicated appendicitis: A case-control study utilizing logistic regression.
Article in World journal of clinical cases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
- Analysis of predictive factors and development of a nomogram for complicated acute appendicitis in adults.BMC surgery · 2026Article
- CT grading combined with inflammatory markers for predicting the efficacy of conservative treatment in acute appendicitis.Clinics (Sao Paulo, Brazil) · 2026Article
- Complicated versus uncomplicated acute appendicitis: clinical characteristics, diagnostic scores, surgical management, and outcomes in a tertiary hospital in Mogadishu, Somalia.Frontiers in surgery · 2026Article
- Perioperative factors influencing post-appendectomy outcomes in adults: a single-center prospective study in the North of Palestine.BMC surgery · 2025Observational
- Combination of clinical information and radiomics models for the differentiation of acute simple appendicitis and non simple appendicitis on CT images.Scientific reports · 2024Article
- Article
- Development of a scoring model based on objective factors to predict gangrenous/perforated appendicitis.BMC gastroenterology · 2023Article
- Pre-appendectomy hyponatremia is associated with increased rates of complicated appendicitis.Surgery open science · 2023Article
- Predictors of complicated appendicitis among patients presented to public referral hospitals in Harari region, Eastern Ethiopia: a case-control study.Surgery in practice and science · 2022Article
- Clinical characteristics of older Japanese patients with acute appendicitis: A post hoc analysis.Journal of general and family medicine · 2022Article
- Characteristics of Patients Presented with Complicated Appendicitis in Adama, Ethiopia: A Cross-Sectional Study.Open access emergency medicine : OAEM · 2022Article
- Reactive leukocytosis in older patients with acute colonic diverticulitis: A retrospective study utilizing logistic regression analysis.Geriatrics & gerontology international · 2020Article
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Authors and funding
13 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSince high-quality evidence on conservative treatment of acute appendicitis using antibiotics has increased, differentiation of patients with complicated appendicitis (CA) from those with simple appendicitis (SA) has become increasingly important. Previous studies have revealed that male gender, advanced age, comorbid conditions, prehospital delay, fever, and anorexia are risk factors of perforated appendicitis. Elevated serum C-reactive protein (CRP) level and hyponatremia have also been reported as predictive biomarkers of CA. However, confounding between various factors is problematic because most previous studies were limited to univariate analysis.
aimTo evaluate non-laboratory and laboratory predictive factors of CA using logistic regression analyses.
methodsWe performed an exploratory, single-center, retrospective case-control study that evaluated 198 patients (83.9%) with SA and 38 patients (16.1%) with CA. Diagnoses were confirmed by computed tomography images for all cases. We compared age, sex, onset-to-visit interval, epigastric/periumbilical pain, right lower quadrant pain, nausea/vomiting, diarrhea, anorexia, medical history (of previous non-surgically treated appendicitis, diabetes, hypertension, dyslipidemia, liver cirrhosis, hemodialysis, chronic lung diseases, malignant tumors, immunosuppressant use, and antiplatelet use), vital signs, physical findings, and laboratory data to select the explanatory variates for logistic regression. Based on the univariate comparisons, we performed logistic regression for clinical differentiation between CA and SA using only non-laboratory factors and also including both non-laboratory and laboratory factors.
resultsThe 236 eligible patients consisted of 198 patients (83.9%) with SA and 38 patients (16.1%) with CA. The median ages were 34 years old [interquartile ranges (IR), 24-45 years] in the SA group and 49 years old (IR, 35-63 years) in the CA group (
conclusionOur logistic regression analysis on differentiating factors of CA from SA showed that high CRP level was a strong dose-dependent predictor of CA.
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