ArticleFrontiers in cell and developmental biology2020
Paget's Disease and Secondary Hyperparathyroidism: Is Healing Possible?
Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Role of Denosumab in Chronic Kidney Disease with Paget's Disease of Bone: A Case Report and Review of Literature.Journal of orthopaedic case reports · 2026Article
- Paget's Disease of Bone and Chronic Kidney Disease: A Review.Journal of clinical medicine · 2026Review
- Paget's Disease of Bone and Normocalcemic Variant of Primary Hyperparathyroidism in an Osteoporotic Male: Exceptional Coexistence.Reports (MDPI) · 2025Article
- Paget's disease of bone and megaloblastic anemia in a 72-year-old patient: A case report and systematic literature review.Experimental and therapeutic medicine · 2022Article
- Extended Trochanteric Osteotomy Combined with Medial Reduction Corticotomy to Correct Femoral Deformity at the Time of Revision Total Hip Arthroplasty.JB & JS open accessArticle
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
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Abstract
Paget bone disease (PDB) is often asymptomatic and incidentally diagnosed. It is a cause of osteoporosis and bone fragility and exposes patients to a high incidence of bone fractures. In Europe the prevalence varies according to the geographical area of origin, and increases with age. In patients with chronic renal disease, the prevalence is unknown and only few cases with PDB have been reported. We present a challenging case in an elderly patient with chronic kidney disease on peritoneal dialysis treatment. Our patients presented extremely high levels of alkaline phosphatase, suggesting a Paget bone disease. Secondary hyperparathyroidism was confirmed by the bone histological examination. The surprising biochemical and clinical response to active vitamin D confirms the well-known role on hyperparathyroidism and may indicate an additional role in the pathogenesis of Paget's disease.
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