Evidence map›Paper›PMID 32547875›Full record

ArticlePeerJ2020

Prognostic significance of PI3K/AKT/ mTOR signaling pathway members in clear cell renal cell carcinoma.

Demin Fan, Qiang Liu, Fei Wu, Na Liu, Hongyi Qu, Yijiao Yuan, Yong Li, Huayu Gao, Juntao Ge, Yue Xu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Demin Fan *Department of Urology, The First Affiliated Hospital of Shandong First Medical University,Jinan, China.
Qiang Liu *Laboratory of Microvascular Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Fei WuDepartment of Urology, The First Affiliated Hospital of Shandong First Medical University,Jinan, China.
Na LiuDepartment of Hematology, Qilu Hospital of Shandong University, Jinan, China.
Hongyi QuDepartment of Pediatric Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Yijiao YuanDepartment of Pediatric Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Yong LiDepartment of Urology, Shandong Yuncheng County Chinese Medicine Hospital, Heze, China.
Huayu GaoDepartment of Pediatric Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Juntao GeDepartment of Pediatric Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Yue XuDepartment of Pediatric Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Hao WangDepartment of Pediatric Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Qingyong LiuDepartment of Urology, The First Affiliated Hospital of Shandong First Medical University,Jinan, China.
Zuohui ZhaoDepartment of Pediatric Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Shandong First Medical University · CNAffiliated Hospital of Shandong University of Traditional Chinese Medicine · CNQilu Hospital of Shandong University · CN

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

backgroundRenal cell carcinoma (RCC) is a fatal disease, in which the PI3K/AKT/mTOR signaling pathway serves an important role in the tumorigenesis. Previous studies have reported the prognostic significance of PI3K/AKT/mTOR signaling pathway members in RCC; however, there is insufficient evidence to date to confirm this. Thus, the present study aimed to systematically investigate the prognostic roles of multiple PI3K/AKT/mTOR signaling proteins in clear cell RCC (ccRCC) using online large-scale databases.

methodsThe mRNA expression profiles of PI3K/AKT/mTOR signaling pathway proteins

resultsThe GEPIA revealed that the mRNA expression of major PI3K/AKT/mTOR pathway members, including

Indexed as

Clear cell renal cell carcinomamTOROverall survivalPTENTCPA

Identifiers

PMID32547875
PMCPMC7271881
OpenAlexW3031151503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.