ArticleJournal of geriatric cardiology : JGC2020
Association of frailty with all-cause mortality and bleeding among elderly patients with acute myocardial infarction: a systematic review and meta-analysis.
Article in Journal of geriatric cardiology : JGC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- The impact of frailty evaluation on the risk of venous thromboembolism in patients with hip fracture following surgery: a meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Frailty Predicts Poor Prognosis of Patients After Percutaneous Coronary Intervention: A Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021Pooled it
- Association Between Claims-Defined Frailty and Outcomes Following 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: Findings From the EXTEND-DAPT Study.Journal of the American Heart Association · 2023Trial
- Frailty scale with the best prediction of mortality in individuals diagnosed with acute coronary syndrome: systematic review and meta-analysis.Journal of geriatric cardiology : JGC · 2026Article
- Inpatient-Onset Versus Outpatient-Onset ST-Segment-Elevation Myocardial Infarction in Patients With Percutaneous Coronary Intervention: A National Registry Study.Journal of the American Heart Association · 2025Article
- Frailty Predicts Mortality and Procedural Performance in Patients With Non-Variceal Upper Gastrointestinal Bleeding.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Phase angle variability on bleeding risks in hemodialysis patients.Clinical and experimental nephrology · 2025Article
- Impact of frailty on outcomes of elderly patients with atrial fibrillation: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Antiplatelet Therapy for Elderly Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.Journal of clinical medicine · 2024Review
- Linking Myocardial Infarction and Frailty Status at Old Age in Europe: Moderation Effects of Country and Gender.Journal of cardiovascular development and disease · 2024Article
- Impact of frailty on outcomes of elderly patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis.World journal of clinical cases · 2024Article
- No Differences in Major In-Hospital Outcome Metrics When Comparing the Direct Lateral Approach to the Posterior Approach for Hemiarthroplasties After Traumatic Displaced Femoral Neck Fractures.Geriatric orthopaedic surgery & rehabilitation · 2024Article
- Frailty as a Predictor of In-Hospital Outcome in Patients with Myocardial Infarction.Journal of cardiovascular development and disease · 2022Article
- Association between frailty and short- and long-term mortality in patients with critical acute myocardial infarction: Results from MIMIC-IV.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is a multidimensional syndrome that reflects the physiological reserve of elderly. It is related to unfavorable outcomes in various cardiovascular conditions. We conducted a systematic review and meta-analysis of the association of frailty with all-cause mortality and bleeding after acute myocardial infarction (AMI) in the elderly.
methodsWe comprehensively searched the databases of MEDLINE and EMBASE from inception to March 2019. The studies that reported mortality and bleeding in AMI patients who were evaluated and classified by frailty status were included. Data from each study were combined using the random-effects, generic inverse variance method of DerSimonian and Laird to calculate hazard ratio (HR), and 95% confidence interval (CI).
resultsTwenty-one studies from 2011 to 2019 were included in this meta-analysis involving 143,301 subjects (mean age 75.33-year-old, 60.0% male). Frailty status was evaluated using different methods such as Fried Frailty Index. Frailty was statistically associated with increased early mortality in nine studies (pooled HR = 2.07, 95% CI: 1.67-2.56,
conclusionFrailty is strongly and independently associated with bleeding, early and late mortality in elderly with AMI. Frailty assessment should be considered as an additional risk factor and used to guide toward personalized treatment strategies.
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Registered trials
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