Evidence map›Paper›PMID 32547559›Full record

ArticleFrontiers in immunology2020

Improved Relapse-Free Survival in Patients With High Natural Killer Cell Doses in Grafts and During Early Immune Reconstitution After Allogeneic Stem Cell Transplantation.

Lia Minculescu, Anne Fischer-Nielsen, Eva Haastrup, Lars Peter Ryder, Niels Smedegaard Andersen, Ida Schjoedt, Lone Smidstrup Friis, Brian Thomas Kornblit, Søren Lykke Petersen, Henrik Sengelov and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  9. Human NK cells and cancer.Oncoimmunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lia MinculescuDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Anne Fischer-NielsenDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Eva HaastrupDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Lars Peter RyderDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Niels Smedegaard AndersenDepartment of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Ida SchjoedtDepartment of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Lone Smidstrup FriisDepartment of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Brian Thomas KornblitDepartment of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Søren Lykke PetersenDepartment of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Henrik SengelovDepartment of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Hanne Vibeke MarquartDepartment of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Copenhagen University Hospital · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mature immunocompetent cells from the stem cell graft as well as early robust immune reconstitution are essential for the graft-vs. -tumor (GVT) effect to eliminate residual malignant cells after allogeneic hematopoietic stem cell transplantation (HSCT). In this prospective study we characterized graft composition of T- and NK cell subsets in 88 recipients of peripheral blood stem cell grafts with multicolor flowcytometry. Our primary aim was to analyze the impact of graft composition on immune reconstitution and clinical outcomes after transplantation. Patients transplanted with graft NK cell doses above the median value of 27 × 10

Indexed as

Hematopoietic Stem Cell TransplantationAdultAgedAllograftsCD56 AntigenFemaleGraft vs Tumor EffectHematologic NeoplasmsHematopoietic Stem Cell MobilizationHumansKiller Cells, NaturalMaleMiddle AgedProspective StudiesSurvival AnalysisT-LymphocytesCD56 Antigenallogeneic transplantationimmune reconstitutioninnate effector cellsnatural killer cellsstem cell graft

Identifiers

PMID32547559
PMCPMC7273963
OpenAlexW3028845187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.