Evidence map›Paper›PMID 32547540›Full record

ReviewFrontiers in immunology2020

Innate Allorecognition and Memory in Transplantation.

Daqiang Zhao, Khodor I Abou-Daya, Hehua Dai, Martin H Oberbarnscheidt, Xian C Li, Fadi G Lakkis

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Immunomodulation by allograft endothelial cells.Frontiers in transplantation · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. The Potential Role of the Leucocyte Immunoglobulin-Like Receptors in Kidney Transplant Rejection: A Mini Review.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daqiang ZhaoThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Khodor I Abou-DayaThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Hehua DaiThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Martin H OberbarnscheidtThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.
Xian C LiImmunobiology & Transplant Science Center and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, United States.
Fadi G LakkisThomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States.

Funding

Innate Recognition of Allogeneic Non-SelfR01AI099465 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKKIS, FADI G. · 2012 to 2022
$4.1M
NIAID NIH HHS R01 AI099465
6 · The paper itself

Abstract

Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation and how to target it is highly desirable. Here, we review the latest advances in innate immunity in transplantation focusing on the roles and mechanisms of innate allorecognition and memory in myeloid cells. These novel concepts could explain why alloimmune response do not abate over time and shed light on new molecular pathways that can be interrupted to prevent or treat chronic rejection.

Indexed as

Graft SurvivalImmunity, InnateImmunologic MemoryTransplantation ToleranceAnimalsGraft RejectionHistocompatibility Antigens Class IHumansImmunosuppressive AgentsIsoantigensOrgan TransplantationTreatment OutcomeHistocompatibility Antigens Class IImmunosuppressive AgentsIsoantigensallorecognitiondendritic cellinnate immunitymonocytetransplantation

Identifiers

PMID32547540
PMCPMC7270276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.