Evidence map›Paper›PMID 32547538›Full record

ArticleFrontiers in immunology2020

Hspa13 Promotes Plasma Cell Production and Antibody Secretion.

Youdi He, Ruonan Xu, Bing Zhai, Ying Fang, Chunmei Hou, Chen Xing, He Xiao, Guojiang Chen, Xiaoqian Wang, Ning Ma and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Youdi HeBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
Ruonan XuBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
Bing ZhaiBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
Ying FangBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
Chunmei HouInstitute of Military Cognition and Brain Sciences, Beijing, China.
Chen XingInstitute of Military Cognition and Brain Sciences, Beijing, China.
He XiaoState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, China.
Guojiang ChenState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, China.
Xiaoqian WangStaidson (Beijing) Biopharmaceuticals Co., Ltd, Beijing, China.
Ning MaDepartment of Rheumatology, First Hospital of Jilin University, Changchun, China.
Gencheng HanInstitute of Military Cognition and Brain Sciences, Beijing, China.
Renxi WangBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
Capital Medical University · CNFirst Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The generation of large numbers of plasma cells (PCs) is a main factor in systemic lupus erythematosus (SLE). We hypothesize that Hspa13, a member of the heat shock protein family, plays a critical role in the control of PC differentiation. To test the hypothesis, we used lipopolysaccharide (LPS)-activated B cells and a newly established mouse line with a CD19

Indexed as

AnimalsAntibodiesAntibody AffinityCase-Control StudiesCells, CulturedDisease Models, AnimalFemaleHSP70 Heat-Shock ProteinsHumansLipopolysaccharidesLupus Erythematosus, SystemicMice, Inbred BALB CMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutMultiple MyelomaAntibodiesHSP70 Heat-Shock ProteinsHSPA13 protein, humanHspa13 protein, mouseLipopolysaccharidesRecombinant Fusion ProteinsTACI receptor-IgG Fc fragment fusion proteinantibodyB cellsHspa13plasma cellsSLE

Identifiers

PMID32547538
PMCPMC7272575
OpenAlexW3028741674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.