ArticleFrontiers in aging neuroscience2020
Induced Suppression of the Left Dorsolateral Prefrontal Cortex Favorably Changes Interhemispheric Communication During Bimanual Coordination in Older Adults-A Neuronavigated rTMS Study.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 17 citations in OpenAlex.
- Frequency-Dependent Whole-Brain Reconfiguration Following Left DLPFC rTMS in Older Adults: A 106-Channel fNIRS Study.Sensors (Basel, Switzerland) · 2026Trial
- The impact of different decibels of ambient noise on attention.Scientific reports · 2026Article
- A transdisciplinary framework for empathy research.Frontiers in human neuroscience · 2026Article
- Functional properties of dorsolateral prefrontal cortex to primary motor cortex connectivity: a dual-site TMS study.Frontiers in human neuroscience · 2026Article
- Synergistic effects of multicomponent exercise and rTMS on sarcopenia and mild cognitive impairment in older people: a protocol for a randomized controlled trial.BMC geriatrics · 2025Article
- Construction and evaluation of a finger motor feedback system to improve finger dexterity.Frontiers in neuroergonomics · 2025Article
- Differences in scalp-to-cortex tissues across age groups, sexes and brain regions: Implications for neuroimaging and brain stimulation techniques.Neurobiology of aging · 2024Article
- Aging and Complexity Effects on Hemisphere-Dependent Movement-Related Beta Desynchronization during Bimanual Motor Planning and Execution.Brain sciences · 2022Article
- Impact of interhemispheric inhibition on bimanual movement control in young and old.Experimental brain research · 2022Article
- Perturbation of cortical activity elicits regional and age-dependent effects on unconstrained reaching behavior: a pilot study.Experimental brain research · 2021Article
- GABA levels are differentially associated with bimanual motor performance in older as compared to young adults.NeuroImage · 2021Article
- Behavioral and Neurophysiological Aspects of Inhibition-The Effects of Acute Cardiovascular Exercise.Journal of clinical medicine · 2021Review
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent transcranial magnetic stimulation (TMS) research indicated that the ability of the dorsolateral prefrontal cortex (DLPFC) to disinhibit the contralateral primary motor cortex (M1) during motor preparation is an important predictor for bimanual motor performance in both young and older healthy adults. However, this DLPFC-M1 disinhibition is reduced in older adults. Here, we transiently suppressed left DLPFC using repetitive TMS (rTMS) during a cyclical bimanual task and investigated the effect of left DLPFC suppression: (1) on the projection from left DLPFC to the contralateral M1; and (2) on motor performance in 21 young (mean age ± SD = 21.57 ± 1.83) and 20 older (mean age ± SD = 69.05 ± 4.48) healthy adults. As predicted, without rTMS, older adults showed compromised DLPFC-M1 disinhibition as compared to younger adults and less preparatory DLPFC-M1 disinhibition was related to less accurate performance, irrespective of age. Notably, rTMS-induced DLPFC suppression restored DLPFC-M1 disinhibition in older adults and improved performance accuracy right after the local suppression in both age groups. However, the rTMS-induced gain in disinhibition was not correlated with the gain in performance. In sum, this novel rTMS approach advanced our mechanistic understanding of how left DLPFC regulates right M1 and allowed us to establish the causal role of left DLPFC in bimanual coordination.
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