Evidence map›Paper›PMID 32547315›Full record

ArticleInternational journal of medical sciences2020

Downregulation of P300/CBP-Associated Factor Attenuates Myocardial Ischemia-Reperfusion Injury Via Inhibiting Autophagy.

Liqiang Qiu, Changwu Xu, Hao Xia, Jing Chen, Huafen Liu, Hong Jiang

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Liqiang QiuDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Changwu XuDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Hao XiaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Jing ChenDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Huafen LiuDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Hong JiangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Renmin Hospital of Wuhan University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiomyocyte autophagy plays an important role in myocardial ischemia-reperfusion injury (MIRI). P300/CBP-associated factor (PCAF) was involved in the regulation of autophagy. However, the role of PCAF in MIRI is currently unknown. This study was to investigate whether downregulation of PCAF attenuate MIRI. The results showed that the expression of PCAF was significantly increased in MIRI

Indexed as

AnimalsAutophagyBlotting, WesternCell LineMagnetic Resonance SpectroscopyMaleMicroscopy, Electron, TransmissionMyocardial Reperfusion InjuryMyocytes, Cardiacp300-CBP Transcription FactorsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsSignal TransductionWortmanninp300-CBP Transcription FactorsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktWortmanninAutophagyMyocardial ischemia-reperfusion injuryP300/CBP-associated factorSignaling pathwayWortmannin

Identifiers

PMID32547315
PMCPMC7294925
OpenAlexW3026792426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.