ArticleCancer management and research2020
hsa_circ_0008285 Facilitates the Progression of Cervical Cancer by Targeting miR-211-5p/SOX4 Axis.
Article in Cancer management and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- SOX4 induces cisplatin resistance in cervical cancer cells by inhibiting aerobic glycolysis.Cell death discovery · 2026Article
- Targeting FOXK2 in triple-negative breast cancer: Role of the P53/MCAS1/miR-211-5p regulatory axis.Functional & integrative genomics · 2025Article
- The Molecular Mechanism by Which miR-211-5p Regulates the Proliferation and Differentiation of Preadipocytes in Meat Rabbits by Targeting TPK1.Animals : an open access journal from MDPI · 2025Article
- Biomarker potential of competing endogenous RNA networks in Polycystic Ovary Syndrome (PCOS).Non-coding RNA research · 2024Review
- Circular RNA circ_0000119 promotes cervical cancer cell growth and migration via miR-433-3p/PAK2 axis.Journal of applied genetics · 2023Article
- CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis.Biochemical genetics · 2023Article
- Has_circ_0008285/miR-211-5p/SIRT-1 Axis Suppress Ovarian Cancer Cells Progression.International journal of molecular and cellular medicine · 2023Article
- circ_0008285 Regulates Glioma Progression via the miR-384/HMGB1 Axis.International journal of genomics · 2023Article
- Circ_0005576 Exerts an Oncogenic Role in Cervical Cancer via miR-1305-Dependent Regulation of PAIP1.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Serum hsa_circ_0079480 is a novel prognostic marker for acute myeloid leukemia.Journal of clinical laboratory analysis · 2022Article
- Role and mechanism of miR-211 in human cancer.Journal of Cancer · 2022Review
- Article
- Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.Cancers · 2021Article
- Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3.Cell death & disease · 2021Article
- The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts.Biological research · 2021Article
- circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway.Journal of Cancer · 2021Article
- Hsa_circ_0079480 promotes tumor progression in acute myeloid leukemia via miR-654-3p/HDGF axis.Aging · 2020Article
- Identification of Functional Genes in Pterygium Based on Bioinformatics Analysis.BioMed research international · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEmerging evidence has demonstrated that circRNAs are implicated in the progression of cervical cancer (CC). However, the roles and underlying mechanisms of circRNAs remain unclear in CC.
methodsQRT-PCR was performed to detect hsa_circ_0008285 expression in CC tissues and cell lines. The roles of hsa_circ_0008285 on CC progression were explored by function assays. Next, the underlying mechanisms of hsa_circ_0008285 in CC progression were determined by bioinformatics analysis, dual-luciferase reporter and RIP assays.
resultsIn the present study, we identified a new circRNA hsa_circ_0008285, which was significantly up-regulated in CC tissues and cell lines. Loss-of-function assays showed that hsa_circ_0008285 suppression reduced the proliferation and invasion of CC cells in vitro and reduced tumor growth in vivo. In mechanism, bioinformatics analysis, dual-luciferase reporter and RIP assays showed that hsa_circ_0008285 served as a sponge for miR-211-5p in CC. Next, we confirmed that SOX4 served as a target gene for miR-211-5p in CC. Additionally, we revealed that miR-211-5p inhibitors abolished the effects of hsa_circ_0008285 on SOX4 expression in CC cells.
conclusionTherefore, our research highlighted that hsa_circ_0008285 promoted CC progression via serving as a ceRNA of miR-211-5p to release SOX4, which might provide a potential therapeutic target for tumor treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.