Evidence map›Paper›PMID 32547160›Full record

ArticleInternational journal of general medicine2020

Golgi Protein 73 versus Alpha-Fetoprotein as a New Biomarker in Early Diagnosis of Hepatocellular Carcinoma.

Omaima Mohamed Ali, Hussein Ahmed El Amin, Yousry Lotfy Sharkawy, Adnan Ahmed Mohamed Ali, Emad Farah Mohammed Kholef, Wael Abd Elgwad Elsewify

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Article in International journal of general medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Hepatitis B virus-induced hepatocellular carcinoma: a persistent global problem.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Omaima Mohamed AliInternal Medicine Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Hussein Ahmed El AminInternal Medicine Department, Faculty of Medicine, Assuit University, Assuit, Egypt.
Yousry Lotfy SharkawyInternal Medicine Department, Faculty of Medicine, Aswan University, Aswan, Egypt.
Adnan Ahmed Mohamed AliTropical Medicine and Gastroenterology Department, Faculty of Medicine, Assuit University, Assuit, Egypt.
Emad Farah Mohammed KholefClinical Pathology Department, Faculty of Medicine, Aswan University, Aswan, Egypt.ORCID 0000-0002-1479-8653
Wael Abd Elgwad ElsewifyInternal Medicine Department, Faculty of Medicine, Aswan University, Aswan, Egypt.ORCID 0000-0002-4382-198X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundScreening of early hepatocellular carcinoma (HCC) diagnosis is the greatest challenge for hepatologists. Alpha-fetoprotein (AFP) is the most common non-invasive biomarker used in HCC diagnosis. OBJECTIVES AND

aimsTo make a comparison between the new biomarker Golgi protein 73 (GP73) versus the standard biomarker AFP in the diagnosis of HCC.

methodsOur study was a case-control study, and 60 patients were included in the study. They were divided into two groups: 1) HCC patients with either chronic HBV or HCV infection (n=30); and 2) non-HCC patients with HBV or HCV infection who had either chronic hepatitis or liver cirrhosis (n=30). In addition, 30 healthy volunteers were included as a control group. Patients were subjected to liver function tests, kidney function tests, serum Golgi protein 73 and AFP levels. Imaging diagnosis of HCC was done by computed tomography (CT) or magnetic resonance imaging (MRI) based on American Association for the Study of Liver Diseases (AASLD) practice guidelines.

resultsStatistically significant differences between groups in terms of serum AFP (

conclusionGolgi protein 73 is a promising and accurate biomarker for early detection of HCC.

Indexed as

AFPGolgi protein 73HCCliver cirrhosis

Identifiers

PMID32547160
PMCPMC7244238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.