ReviewClinical and experimental gastroenterology2020
Toxic Megacolon: Background, Pathophysiology, Management Challenges and Solutions.
Review in Clinical and experimental gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Effects of cuproptosis and its application in inflammatory bowel disease (Review).International journal of molecular medicine · 2026Review
- Persistent non-toxic megacolon in ulcerative colitis: a case report of broad disruption and scar replacement of the muscularis propria.Clinical journal of gastroenterology · 2026Article
- Toxic Megacolon With a Positive Clostridioides difficile Antigen but Negative Toxin Assay.Cureus · 2026Article
- Familial adult-onset chronic idiopathic megacolon: diagnostic and surgical challenges-a case report.Journal of surgical case reports · 2026Article
- The Gut Microbiome in Enteric Viral Infections: Underlying Mechanisms and Therapeutic Approaches.Microorganisms · 2025Review
- Article
- Article
- Fatal Toxic Megacolon Following Nivolumab and Ipilimumab Therapy in Metastatic Melanoma: A Case Report.Cureus · 2025Article
- A novel case of aripiprazole and clomipramine-induced toxic megacolon: enough to drive anyone mad.Journal of surgical case reports · 2025Article
- Cross-sectional imaging of mimics of inflammatory bowel disease: not everything is Crohn's disease or ulcerative colitis.Abdominal radiology (New York) · 2025Review
- Article
- Therapeutics involved in managing initial and recurrentWorld journal of gastrointestinal pharmacology and therapeutics · 2024Review
- Revolutionizing Gastrointestinal Disorder Management: Cutting-Edge Advances and Future Prospects.Journal of clinical medicine · 2024Review
- From Hemorrhage to Diarrhea: The Comprehensive Clinical Journey of a Patient With Pseudomembranous Colitis.Cureus · 2024Article
- Toxic megacolon: a potentially lethal condition. Case report.Journal of surgical case reports · 2024Article
- [Emergency diagnoses in the gastrointestinal tract].Radiologie (Heidelberg, Germany) · 2024Article
- Surgical Management for Patients with Toxic Megacolon due to Ulcerative Colitis.Journal of the anus, rectum and colon · 2024Article
- Article
- Thyroid disorders and gastrointestinal dysmotility: an old association.Frontiers in physiology · 2024Review
- Negative pressure therapy in pediatric patient with surgical site infection: experience report.Revista da Escola de Enfermagem da U S P · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxic megacolon (TM) is one of the fatal complications of inflammatory bowel disease (IBD) or any infectious etiology of the colon that is characterized by total or partial nonobstructive colonic dilatation and systemic toxicity. It is associated with high morbidity and mortality, and surgical management is necessary for the majority of the cases. An accurate history and physical examination, plain radiographs of the abdomen, sigmoidoscopy, and, most important of all, awareness of the condition facilitate diagnosis in most cases. Operative intervention is warranted when massive hemorrhage, perforation, or peritonitis complicate the clinical scenario or medical therapy fails to control the disease. We sought to review the management challenges of TM and its possible management strategies in this article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.