Evidence map›Paper›PMID 32547085›Full record

ArticleOncoTargets and therapy2020

CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p.

Fengchun Liu, Yanru Fan, Liping Ou, Ting Li, Jiaxin Fan, Limei Duan, Jinxiao Yang, Chunli Luo, Xiaohou Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review.Frontiers in cell and developmental biology · 2021
    Pooled it
  4. Article
  5. Review
  6. Review
  7. Review
  8. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Role of Circular RNAs in Prostate Cancer.Current medicinal chemistry · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Circular RNAs in organ injury: recent development.Journal of translational medicine · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fengchun LiuDepartment of Laboratory Diagnosis, Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.
Yanru FanDepartment of Laboratory Diagnosis, Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.
Liping OuDepartment of Laboratory Diagnosis, Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.
Ting LiDepartment of Laboratory Diagnosis, Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.
Jiaxin FanDepartment of Laboratory Diagnosis, Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.
Limei DuanDepartment of Laboratory Diagnosis, Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.
Jinxiao YangDepartment of Laboratory Diagnosis, Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.
Chunli LuoDepartment of Laboratory Diagnosis, Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.ORCID 0000-0002-6400-5631
Xiaohou WuDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing 408000, People's Republic of China.
Chongqing Medical University · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs) play a crucial role in gene expression regulation. CircHIPK3 is a circRNA derived from Exon 2 of HIPK3 gene and its role in prostate cancer (PCa) is still unclear.

methodsCCK8 assays, flow cytometry and colony formation assays were performed to assess the effects of circHIPK3 in PCa cells. Bioinformatics analysis, RNA pull-down assay, RNA immunoprecipitation assay (RIP), and luciferase activity assay were performed to dissect the mechanism underlying circHIPK3-mediated G2/M transition in PCa cells.

resultsCircHIPK3 expression was upregulated in PCa cells and prostate cancer tissues. Overexpression of circHIPK3 or circHIPK3 silencing altered PCa viability, proliferation and apoptosis in vitro. CircHIPK3 could sponge miR-338-3p and inhibit its activity, resulting in increased expression of Cdc25B and Cdc2 in vitro.

conclusionCircHIPK3 promotes G2/M transition and induces PCa cell proliferation by sponging miR-338-3p and increasing the expression of Cdc25B and Cdc2. CircHIPK3 may play an oncogenic role in PCa.

Indexed as

Cdc25BcircHIPK3G2/M transitionmiR-338-3pprostate cancer

Identifiers

PMID32547085
PMCPMC7251229
OpenAlexW3026886583

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.