Evidence map›Paper›PMID 32547034›Full record

ArticleNeuropsychiatric disease and treatment2020

Decreased Risk of Influenza in Child and Adolescent Patients with Attention-Deficit Hyperactivity Disorder Following Methylphenidate Treatment: A Nationwide Cohort Study in Taiwan.

Hsuan Lee, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Tzu-Chin Lin, Shu-I Wu, Kai-Liang Kao, Jun-Cheng Weng, Brent Allan Kelsen, Sophie Hsin-Yi Liang

Open access · goldAbstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Hsuan Lee *Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0001-8143-3630
Vincent Chin-Hung Chen *Department of Medicine, Chang Gung University, Taoyuan, Taiwan.
Yao-Hsu YangHealth Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi Branch, Chiayi,Taiwan.ORCID 0000-0002-8080-0504
Ting-Yu KuoHealth Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi Branch, Chiayi,Taiwan.
Tzu-Chin LinBethel Psychiatric Clinic, Taipei, Taiwan.
Shu-I WuMackay Memorial Hospital, Section of Psychiatry, Taipei, Taiwan.
Kai-Liang KaoDepartment of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan.
Jun-Cheng WengDepartment of Psychiatry, Chang Gung Memorial Hospital at Chiayi,Chiayi,Taiwan.ORCID 0000-0001-7616-6216
Brent Allan KelsenLanguage Center, National Taipei University, New Taipei City, Taiwan.ORCID 0000-0001-5599-0011
Sophie Hsin-Yi LiangDepartment of Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0003-4381-5173
Chang Gung University · TWAsia Eastern University of Science and Technology · TWAuckland University of Technology · NZChiayi Chang Gung Memorial Hospital · TWMackay Memorial Hospital · TWNational Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundYoung individuals with attention-deficit hyperactivity disorder (ADHD) may have an elevated risk of influenza because of the difficulty in complying with the behavioral procedures that help protect against influenza. Moreover, the effects of sufficient methylphenidate treatment on influenza have received little attention.

objectiveThis study evaluated the association between ADHD medication usage and influenza and assessed the effect of duration of ADHD treatment on the risk of influenza using a nationwide population-based database.

methodsThis study investigated methylphenidate usage and the risk of influenza among children and adolescents with ADHD. We identified 5259 young individuals aged less than 18 years who were diagnosed as having ADHD between 1996 and 2013 from the National Health Insurance Research Database of Taiwan, and we tested whether methylphenidate use affects influenza risk using Cox proportional hazard models.

resultsAfter controlling for confounding factors, the results indicated that influenza risk significantly reduced in the group of ADHD patients who were prescribed methylphenidate for 90 days and more (hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.52-0.75,

conclusionThe lower incidence of influenza observed in the group prescribed with methylphenidate for a longer period highlights the importance of compliance to medication and psychoeducation with regard to ADHD management.

Indexed as

ADHDinfluenzamethylphenidate

Identifiers

PMID32547034
PMCPMC7247598
OpenAlexW3027436049

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.