ArticleInternational journal of nanomedicine2020
Synergistic ROS-Associated Antimicrobial Activity of Silver Nanoparticles and Gentamicin Against
Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 82 citations in OpenAlex.
- Phytochemical Profiling, Antioxidant and Antibacterial Activities ofAnimals : an open access journal from MDPI · 2026Article
- Enzyme therapy as a promising strategy to overcome multi-drug resistance in pathogens: current advances, key challenges, and future directions.RSC advances · 2026Review
- Nanosystems for delivery of indolicidin peptide.Frontiers in medical technology · 2026Review
- Chitosan-coated silver nanoparticles amplify glycopeptide efficacy againstFrontiers in microbiology · 2026Article
- Article
- Caffeic Acid and Erythromycin: Antibacterial and Synergistic Effects on Staphylococci.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Functional Properties and Safety Considerations of Zinc Oxide Nanoparticles Under Varying Conditions.Nanomaterials (Basel, Switzerland) · 2025Article
- Silver Nanoparticles and Antibiotics: A Promising Synergistic Approach to Multidrug-Resistant Infections.Microorganisms · 2025Review
- Addressing the global challenge of bacterial drug resistance: insights, strategies, and future directions.Frontiers in microbiology · 2025Review
- A Multifunctional Nanozyme Hydrogel with Antibacterial, Antioxidative, and Photo-Induced Nitric Oxide-Supplying Properties for Promoting Infected Wound Healing.Pharmaceutics · 2024Article
- Green synthesized silver nanoparticles, a sustainable approach for fruit and vegetable preservation: An overview.Food chemistry: X · 2024Review
- Microbe-drug association prediction model based on graph convolution and attention networks.Scientific reports · 2024Article
- Advancements in Aerogel Technology for Antimicrobial Therapy: A Review.Nanomaterials (Basel, Switzerland) · 2024Review
- SilversolPharmaceutics · 2024Article
- Structural Characterization and Bioactivity of a Titanium(IV)-Oxo Complex Stabilized by Mandelate Ligands.Molecules (Basel, Switzerland) · 2024Article
- Green Synthesis of Narrow-Size Silver Nanoparticles UsingInternational journal of molecular sciences · 2024Article
- Antimicrobial and antibiofilm effects of cyclic dipeptide-rich fraction fromFrontiers in microbiology · 2024Article
- Employment of Spore-Forming Probiotics to Combat Persister Cells ofReports of biochemistry & molecular biology · 2024Article
- Advances in silver nanoparticles: a comprehensive review on their potential as antimicrobial agents and their mechanisms of action elucidated by proteomics.Frontiers in microbiology · 2024Review
- The Direction of the Antibacterial Effect of Rutin Hydrate and Amikacin.Antibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIncreasing bacteria resistance to antibiotics is a major problem of healthcare system. There is a need for solutions that broaden the spectrum of bactericidal agents improving the efficacy of commonly used antibiotics. One of the promising directions of search are silver nanoparticles (obtained by different methods and displaying diversified physical and chemical properties), and their combination with antibiotics. PURPOSE: In this study, we tested the role of reactive oxygen species in the mechanism of synergistic antibacterial activity of gentamicin and Tween-stabilized silver nanoparticles against gentamicin-resistant clinical strains of
methodsSynergistic bactericidal activity of gentamicin and silver nanoparticles stabilized with non-ionic detergent (Tween 80) was tested by the checkerboard titration method on microtiter plates. Detection of reactive oxygen species was based on the chemiluminescence of luminol.
resultsHydrophilic non-ionic surface functionalization of silver nanoparticles enabled the existence of non-aggregated active nanoparticles in a complex bacterial culture medium. Tween-stabilized silver nanoparticles in combination with gentamicin exhibited bactericidal activity against multidrug-resistant biofilm forming clinical strains of
conclusionGeneration of reactive oxygen species by Tween-coated metallic silver nanoparticles was significantly enhanced by gentamicin, confirming the hypothesis of oxidative-associated mechanism of the synergistic antibacterial effect of the gentamicin-silver nanoparticles complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.