Evidence map›Paper›PMID 32546971›Full record

ArticleDrug design, development and therapy2020

Synthesis and Biological Activity of Piperine Derivatives as Potential

Yanli Wang, Yuan Yao, Jing Liu, Lili Wu, Tonghua Liu, Jian Cui, David Yue-Wei Lee

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yanli WangSchool of Pharmacy, Minzu University of China, Beijing 100081, People's Republic of China.ORCID 0000-0001-5807-3497
Yuan YaoState Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, People's Republic of China.
Jing LiuBio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, Boston, MA 02478, USA.
Lili WuSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Tonghua LiuSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Jian CuiSchool of Pharmacy, Minzu University of China, Beijing 100081, People's Republic of China.
David Yue-Wei LeeBio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, Boston, MA 02478, USA.
Harvard University · USBeijing University of Chinese Medicine · CNInner Mongolia University · CNMinzu University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPeroxisome proliferator-activated receptor MATERIALS AND

methodsIn the research, we synthesized a series of piperine derivatives and then used a fluorescence polarization-based

resultsA total of 30 piperine derivatives were synthesized and evaluated. Compound

Indexed as

AlkaloidsBenzodioxolesCells, CulturedDose-Response Relationship, DrugHumansLigandsMolecular Docking SimulationMolecular StructurePiperidinesPolyunsaturated AlkamidesPPAR gammaStructure-Activity RelationshipAlkaloidsBenzodioxolesLigandsPiperidinespiperinePolyunsaturated AlkamidesPPAR gammaligand screening assaymolecular dockingpiperine derivativesPPARγ

Identifiers

PMID32546971
PMCPMC7266110
OpenAlexW3027891577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.