Evidence map›Paper›PMID 32546840›Full record

ReviewNature reviews. Cancer2020

Prostate carcinogenesis: inflammatory storms.

Johann S de Bono, Christina Guo, Bora Gurel, Angelo M De Marzo, Karen S Sfanos, Ram S Mani, Jesús Gil, Charles G Drake, Andrea Alimonti

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 5 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 5 syntheses or guidelines pooled it, 235 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Johann S de Bono *The Institute of Cancer Research, London, UK. johann.de-bono@icr.ac.uk.ORCID http://orcid.org/0000-0002-2034-595X
Christina Guo *The Institute of Cancer Research, London, UK.
Bora GurelThe Institute of Cancer Research, London, UK.
Angelo M De MarzoJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Karen S SfanosJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Ram S ManiDepartment of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.
Jesús GilMRC London Institute of Medical Sciences (LMS), London, UK.ORCID http://orcid.org/0000-0002-4303-6260
Charles G DrakeColumbia University Medical Center, New York, NY, USA.
Andrea AlimontiInstitute of Oncology Research, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-9362-2313
Johns Hopkins University · USRoyal Marsden NHS Foundation Trust · GBColumbia University Irving Medical Center · USInstitute of Cancer Research · GBMRC London Institute of Medical Sciences · GBSouthwestern Medical Center · USUniversity of Padua · IT

Funding

3D genome architecture and the origins of recurrent genomic rearrangements in prostate cancerR01CA245294 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MANI, RAM SHANKAR · 2020 to 2024
$1.9M
Cancer Research UK 28647Department of HealthMedical Research Council MC_U120085810NCI NIH HHS R01 CA245294
6 · The paper itself

Abstract

Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an altered microbiome being causally implicated. Intra-prostatic inflammatory cell recruitment and expansion can ultimately promote DNA double-strand breaks and androgen receptor activation in prostate epithelial cells. The activation of the senescence-associated secretory phenotype fuels further 'inflammatory storms', with free radicals leading to further DNA damage. This drives the overexpression of DNA repair and tumour suppressor genes, rendering these genes susceptible to mutagenic insults, with carcinogenesis accelerated by germline DNA repair gene defects. We provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries.

Indexed as

CarcinogenesisCell Transformation, NeoplasticChronic DiseaseDietDietary FatsDNA Breaks, Double-StrandedDNA DamageDNA RepairHumansInflammationMaleMicrobiotaObesityParacrine CommunicationProstateProstatic NeoplasmsDietary FatsReceptors, Androgen

Identifiers

PMID32546840
OpenAlexW3035486298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.