ArticleScientific reports2020
Ergot alkaloid mycotoxins: physiological effects, metabolism and distribution of the residual toxin in mice.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Plant Fungal Endophytes as Sustainable Components of Insect Pest Management.Current microbiology · 2026Review
- A New Frontier in Food Safety: Cold Plasma Strategies for Effective Control of Fungi and Mycotoxins.Toxins · 2026Review
- Mycotoxin management in Sub-Saharan Africa: A comprehensive systematic review of policies and strategies in Malawi.Toxicology reports · 2025Review
- Rye (Frontiers in nutrition · 2025Review
- First Synthesis of Ergotamine-Toxins · 2024Article
- The C-8-S-isomers of ergot alkaloids - a review of biological and analytical aspects.Mycotoxin research · 2024Review
- Risks for animal health related to the presence of ergot alkaloids in feed.EFSA journal. European Food Safety Authority · 2024Article
- Recent Advances in the Detection of Food Toxins Using Mass Spectrometry.Chemical research in toxicology · 2023Review
- Effect of increasing concentration of ergot alkaloids in the diet of feedlot cattle: performance, welfare, and health parameters.Journal of animal science · 2023Article
- Investigation of the relationship between ergocristinine and vascular receptors.Toxicology reports · 2023Article
- A Metabolomic Study ofMetabolites · 2022Article
- Metabolic Potential ofMicroorganisms · 2021Review
- The Known Antimammalian and Insecticidal Alkaloids Are Not Responsible for the Antifungal Activity ofPlants (Basel, Switzerland) · 2021Article
- Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model.Scientific reports · 2021Article
- Article
- The Impact of Alkaloid-ProducingToxins · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complex ergot alkaloids, ergovaline and ergotamine, cause dysregulation of physiological functions, characterised by vasoconstriction as well as thermoregulatory and cardiovascular effects in grazing livestock. To assess the effect of the mycotoxins, blood pressure and heart rate of male mice were measured, and metabolite profiling undertaken to determine relative abundances of both ergotamine and its metabolic products in body and brain tissue. Ergotamine showed similar cardiovascular effects to ergovaline, causing elevations in blood pressure and reduced heart rate. Bradycardia was preserved at low-levels of ergovaline despite no changes in blood pressure. Ergotamine was identified in kidney, liver and brainstem but not in other regions of the brain, which indicates region-specific effects of the toxin. The structural configuration of two biotransformation products of ergotamine were determined and identified in the liver and kidney, but not the brain. Thus, the dysregulation in respiratory, thermoregulatory, cardiac and vasomotor function, evoked by ergot alkaloids in animals observed in various studies, could be partially explained by dysfunction in the autonomic nervous system, located in the brainstem.
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