Evidence map›Paper›PMID 32546796›Full record

Trial reportScientific reports2020

Physical deterioration and adaptive recovery in physically inactive breast cancer patients during adjuvant chemotherapy: a randomised controlled trial.

Tom Møller, Christina Andersen, Christian Lillelund, Kira Bloomquist, Karl Bang Christensen, Bent Ejlertsen, Malgorzata Tuxen, Peter Oturai, Ulla Breitenstein, Cecilie Kolind and 4 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 8 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 8 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  4. Pooled it
  5. Pooled it
  6. The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  7. Long-term effects of exercise interventions on physical activity in breast cancer patients: a systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  8. Pooled it
  9. Trial
  10. Trial
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  12. Article
  13. Review
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  15. What works to engage cancer patients with fatigue in exercise: a scoping review of RCT-based interventions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  16. Review
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Tom MøllerThe University Hospitals Centre for Health Research (UCSF), Copenhagen University Hospital, Rigshospitalet, Department, 9701, Copenhagen, Denmark. tommoel@icloud.com.ORCID http://orcid.org/0000-0003-1908-258X
Christina AndersenThe University Hospitals Centre for Health Research (UCSF), Copenhagen University Hospital, Rigshospitalet, Department, 9701, Copenhagen, Denmark.
Christian LillelundThe University Hospitals Centre for Health Research (UCSF), Copenhagen University Hospital, Rigshospitalet, Department, 9701, Copenhagen, Denmark.
Kira BloomquistThe University Hospitals Centre for Health Research (UCSF), Copenhagen University Hospital, Rigshospitalet, Department, 9701, Copenhagen, Denmark.
Karl Bang ChristensenUniversity of Copenhagen, Faculty of Health and Medical Sciences, Department of Public Health, Copenhagen, Denmark.
Bent EjlertsenCopenhagen University Hospital, Rigshospitalet, Department of Oncology, 7301, Copenhagen, Denmark.
Malgorzata TuxenCopenhagen University Hospital, Rigshospitalet, Department of Oncology, 7301, Copenhagen, Denmark.
Peter OturaiCopenhagen University Hospital, Rigshospitalet, Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen, Denmark.
Ulla BreitensteinCopenhagen University Hospital, Rigshospitalet, Department of Oncology, 7301, Copenhagen, Denmark.
Cecilie KolindCopenhagen University Hospital, Herlev Hospital, Department of Oncology, Herlev, Denmark.
Pernille TravisCopenhagen University Hospital, Herlev Hospital, Department of Oncology, Herlev, Denmark.
Tina BjergCopenhagen University Hospital, Rigshospitalet, Department of Oncology, 7301, Copenhagen, Denmark.
Mikael RørthCopenhagen University Hospital, Rigshospitalet, Department of Oncology, 7301, Copenhagen, Denmark.
Lis AdamsenThe University Hospitals Centre for Health Research (UCSF), Copenhagen University Hospital, Rigshospitalet, Department, 9701, Copenhagen, Denmark.
Copenhagen University Hospital · DKUniversity of Copenhagen · DKHerlev Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiorespiratory fitness is an independent risk factor for cardiovascular disease and shortened life expectancy in breast cancer survivors. This randomised controlled trial (n = 153) was designed for patients with a physically inactive lifestyle prediagnosis and concurrently referred to adjuvant chemotherapy. We compared two 12-week exercise interventions aimed at physiological and patient-reported outcomes (cardiorespiratory fitness, muscle strength, metabolic markers, physical activity, pain, fatigue), including a 39-week follow-up. A supervised hospital-based moderate to high intensity group exercise intervention was compared to an instructed home-based individual pedometer intervention. The two 12-week interventions included oncologists' recommendations and systematic health counselling. Outcomes were measured at baseline and week 6, 12 and 39. Primary outcome cardiorespiratory fitness declined significantly during chemotherapy and was restored in both interventions at follow-up. The interventions effectively engaged breast cancer patients in sustaining physical activities during and following adjuvant treatment. A composite metabolic score improved significantly. Positive cardiorespiratory fitness responders had improved clinical effects on fatigue, pain and dyspnoea versus negative responders. We conclude that a loss of cardiorespiratory fitness among physically inactive breast cancer patients may be restored by early initiated interventions and by adapting to physical activity recommendations, leading to a decreased cardiovascular risk profile in breast cancer survivors.

Indexed as

Adjuvants, ImmunologicAdjuvants, PharmaceuticAdultBreastBreast NeoplasmsCancer SurvivorsCardiorespiratory FitnessChemotherapy, AdjuvantExerciseExercise TherapyFatigueFemaleHumansMiddle AgedMuscle StrengthPhysical FitnessAdjuvants, ImmunologicAdjuvants, Pharmaceutic

Identifiers

PMID32546796
PMCPMC7297957
OpenAlexW3035145066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.