ArticleNature communications2020
Motion corrected MRI differentiates male and female human brain growth trajectories from mid-gestation.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Brain charts for neuroanatomical sex differences across the human lifespan.bioRxiv : the preprint server for biology · 2026Article
- Imaging of Embryonic and Fetal Brain Development Using MRI Microscopy: Achieving High Spatial Resolution.Medical sciences (Basel, Switzerland) · 2026Review
- Normative growth trajectories of fetal brain regions validated by satisfactory maturation of neurodevelopmental domains at 2 years of age.Nature communications · 2026Article
- Mapping brain growth and sex differences across prenatal to postnatal development.Scientific reports · 2026Article
- Before hormones: early sex-specific mechanisms shaping nervous system development, function, and postnatal disease susceptibility.Frontiers in behavioral neuroscience · 2026Review
- Sulcal pits as potential markers of early sex-related human brain differences in healthy adults.Biology of sex differences · 2025Article
- The longitudinal effects of neonatal anthropometry on attention problems in males and females.JCPP advances · 2025Article
- Burst of gyrification in the human brain after birth.Communications biology · 2025Article
- Establishing group-level brain structural connectivity incorporating anatomical knowledge under latent space modeling.Medical image analysis · 2025Article
- Characterization of normative fetal rhesus macaque brain development with magnetic resonance imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sex-specific effects of birth weight on longitudinal behavioural outcomes in children and adolescents: findings from the raine study.European child & adolescent psychiatry · 2024Article
- Sex-Specific Effects of Birth Weight on Longitudinal Behavioral Outcomes: A Mendelian Randomization Approach Using Polygenic Scores.Biological psychiatry global open science · 2024Article
- Using Organoids to Model Sex Differences in the Human Brain.Biological psychiatry global open science · 2024Review
- Longitudinal MRI of the developing ferret brain reveals regional variations in timing and rate of growth.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Visuospatial Function in Women with Premenstrual Dysphoric Disorder.Journal of clinical medicine · 2024Article
- Article
- Investigating the neurobiology of maternal opioid use disorder and prenatal opioid exposure using brain organoid technology.Frontiers in cellular neuroscience · 2024Review
- Sex differences in normal fetal regional brain apparent diffusion coefficient changes assessed byFrontiers in pediatrics · 2024Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
It is of considerable scientific, medical, and societal interest to understand the developmental origins of differences between male and female brains. Here we report the use of advances in MR imaging and analysis to accurately measure global, lobe and millimetre scale growth trajectory patterns over 18 gestational weeks in normal pregnancies with repeated measures. Statistical modelling of absolute growth trajectories revealed underlying differences in many measures, potentially reflecting overall body size differences. However, models of relative growth accounting for global measures revealed a complex temporal form, with strikingly similar cortical development in males and females at lobe scales. In contrast, local cortical growth patterns and larger scale white matter volume and surface measures differed significantly between male and female. Many proportional differences were maintained during neurogenesis and over 18 weeks of growth. These indicate sex related sculpting of neuroanatomy begins early in development, before cortical folding, potentially influencing postnatal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.