ArticleNature communications2020
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression.Cancer research · 2026Article
- Horizontal transfer of nuclear DNA in transmissible cancer.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate.Communications biology · 2024Article
- Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule.Nature cancer · 2023Article
- A deep dive into transmissible cancer evolution in bivalve mollusks.Nature cancer · 2023Article
- Centuries of genome instability and evolution in soft-shell clam, Mya arenaria, bivalve transmissible neoplasia.Nature cancer · 2023Article
- Bridging clinic and wildlife care with AI-powered pan-species computational pathology.Nature communications · 2023Article
- Mitochondria on the move: Horizontal mitochondrial transfer in disease and health.The Journal of cell biology · 2023Article
- Targeting metabolic vulnerabilities to overcome resistance to therapy in acute myeloid leukemia.Cancer drug resistance (Alhambra, Calif.) · 2023Review
- Population genetics of clonally transmissible cancers.Nature ecology & evolution · 2022Review
- Prevalence and polymorphism of a mussel transmissible cancer in Europe.Molecular ecology · 2022Article
- Role of the mtDNA Mutations and Mitophagy in Inflammaging.International journal of molecular sciences · 2022Review
- Article
- MtDNA sequence features associated with 'selfish genomes' predict tissue-specific segregation and reversion.Nucleic acids research · 2020Article
Corrections and comments
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Authors and funding
89 authors at 20 institutions in 29 countries.
Andrea StrakovaTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6221-5515
Thomas J Nicholls *Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-3034-4109
Adrian Baez-Ortega *Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9201-4420
Máire Ní LeathlobhairTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Alexander T SampsonTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Katherine HughesDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3331-1249
Isobelle A G BoltonTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Kevin GoriTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7975-4275
Jinhong WangTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Ilona Airikkala-OtterWorldwide Veterinary Service, International Training Center, Tamil Nadu, India.
Janice L AllenAnimal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
Karen M AllumWorld Vets, Gig Harbor, USA.
Clara L ArnoldHopkins Belize Humane Society, Hopkins, Belize.
Leontine Bansse-IssaAnimal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
Thinlay N BhutiaSikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, Sikkim, India.
Jocelyn L BissonTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5337-1807
Kelli BlankHopkins Belize Humane Society, Hopkins, Belize.
Cristóbal BriceñoConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.ORCID http://orcid.org/0000-0001-8999-650X
Artemio Castillo DomrachevaCorozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama.
Anne M CorriganSt. George's University, True Blue, Grenada.
Hugh R CranThe Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.
Jane T CrawfordAnimal Medical Centre, Belize City, Belize.
Stephen M CutterAnimal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
Eric DavisInternational Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, USA.
Karina F de CastroCentro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil.
Andrigo B De NardiSchool of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, Brazil.ORCID http://orcid.org/0000-0001-6463-2144
Anna P de VosLadybrand Animal Clinic, Ladybrand, South Africa.
Laura Delgadillo KeenanVeterinary Clinic Sr. Dog's, Guadalajara, Mexico.
Edward M DonelanAnimal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
Adela R Espinoza HuertaWorld Vets Latin America Veterinary Training Center, Granada, Nicaragua.
Ibikunle A FaramadeNational Veterinary Research Institute, Vom, Nigeria.
Mohammed FazilAnimal Clinic, Mombasa, Kenya.
Eleni FotopoulouIntermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece.
Skye N FrueanAnimal Protection Society of Samoa, Apia, Samoa.
Fanny Gallardo-ArrietaFaculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.
Olga GlebovaVeterinary Clinic BIOCONTROL, Moscow, Russia.
Pagona G GouletsouFaculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.ORCID http://orcid.org/0000-0001-5399-0528
Rodrigo F Häfelin ManriqueVeterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile.
Joaquim J G P HenriquesOnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal.ORCID http://orcid.org/0000-0002-2293-2277
Rodrigo S HortaUniversidade Vila Velha, Vila Velha, Brazil.ORCID http://orcid.org/0000-0002-9885-4498
Natalia IgnatenkoVeterinary Clinic Zoovetservis, Kiev, Ukraine.
Yaghouba KaneÉcole Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal.
Cathy KingWorld Vets, Gig Harbor, USA.
Debbie KoenigWorld Vets, Gig Harbor, USA.
Ada KrupaDepartment of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Steven J KruzeniskiWorld Vets Latin America Veterinary Training Center, Granada, Nicaragua.
Marta Lanza-PereaSt. George's University, True Blue, Grenada.
Mihran LazyanVetexpert Veterinary Group, Yerevan, Armenia.
Adriana M Lopez QuintanaLopez Quintana Veterinary Clinic, Maldonado, Uruguay.
Thibault LosfeltClinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France.
Gabriele MarinoDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
Simón Martínez CastañedaFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.
Mayra F Martínez-LópezSchool of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.ORCID http://orcid.org/0000-0001-9149-3960
Bedan M MasuruliVeterinary Council of Tanzania, Dar-es-Salaam, Tanzania.
Michael MeyerTouray & Meyer Vet Clinic, Serrekunda, The Gambia.
Edward J MignecoHillside Animal Hospital, St. Louis, USA.
Berna NakanwagiThe Kampala Veterinary Surgery, Kampala, Uganda.
Karter B NealAsavet Veterinary Charities, Tucson, USA.
Winifred NeunzigWorld Vets, Gig Harbor, USA.
Sally J NixonVets Beyond Borders, Bylakuppe, India.
Antonio Ortega-PachecoFaculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.
Francisco Pedraza-OrdoñezLaboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.ORCID http://orcid.org/0000-0002-3217-8941
Maria C PeleteiroCentre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.ORCID http://orcid.org/0000-0003-1848-558X
Katherine PolakFour Paws International, Vienna, Austria.
Ruth J PyeVets Beyond Borders, The Rocks, Australia.
Juan C Ramirez-AnteLaboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.ORCID http://orcid.org/0000-0003-3747-7462
John F ReeceHelp in Suffering, Jaipur, India.
Jose Rojas GutierrezVeterinary Clinic Dr José Rojas, Los Andes, Chile.
Haleema SadiaDepartment of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.ORCID http://orcid.org/0000-0002-6350-8077
Sheila K SchmelingCorozal Veterinary Clinic, Corozal Town, Belize.
Olga ShamanovaVeterinary Clinic Vetmaster, Ramenskoye, Russia.
Alan G SherlockVets Beyond Borders, The Rocks, Australia.
Audrey E Steenland-SmitAnimal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
Alla SvitichState Hospital of Veterinary Medicine, Kamianske, Ukraine.
Lester J Tapia MartínezWorld Vets Latin America Veterinary Training Center, Granada, Nicaragua.
Ismail Thoya NgokaJomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
Cristian G TorresLaboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.
Elizabeth M TudorFaculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia.
Mirjam G van der WelAnimal Anti Cruelty League, Port Elizabeth, South Africa.
Bogdan A VițălaruClinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania.
Sevil A VuralDepartment of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.ORCID http://orcid.org/0000-0003-2111-3381
Oliver WalkintonVets Beyond Borders, The Rocks, Australia.
Alvaro S Wehrle-MartinezFaculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.
Sophie A E WiddowsonLilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi.
Irina ZvarichVeterinary clinic Canine Heart, Yelizovo, Russia.
Patrick F ChinneryMRC-Mitochondrial Biology Unit & Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Maria FalkenbergDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
Claes M GustafssonDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
Elizabeth P MurchisonTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. epm27@cam.ac.uk.ORCID http://orcid.org/0000-0001-7462-8907
University of Cambridge · GBUniversity of Chile · CLSt. George's University · GDUniversity of Caldas · COUniversity of Gothenburg · SEAnimal Welfare Institute · USAnkara University · TRAutonomous University of Yucatán · MXBalochistan University of Information Technology, Engineering and Management Sciences · PKCatholic Charities · USCentral America Health Sciences University · BZCentro Hospitalar de Lisboa Ocidental · PTCentro Universitário de Rio Preto · BRChristian Health Association of Malawi · MWÉcole Inter-États des Sciences et Médecine Vétérinaires de Dakar · SNGovernment of Sikkim · INJomo Kenyatta University of Agriculture and Technology · KEKampala University · UGKenya Land Alliance · KENational University of Samoa · WS
Funding
Department of HealthMedical Research Council MC_UP_1501/2Wellcome TrustWellcome Trust 102942/Z/13/AWellcome Trust 212219/Z/18/ZWellcome Trust 213464/Z/18/Z
Abstract
Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.
Indexed as
HaplotypesAnimalsDNA, MitochondrialDog DiseasesDogsGene Transfer, HorizontalPhylogenyPolymorphism, GeneticRecurrenceSelection, GeneticVenereal Tumors, VeterinaryDNA, Mitochondrial
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