ArticleScientific reports2020
Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 3 of them syntheses that pooled it.
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Who cites it
106 citing papers in PubMed, 3 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- Pooled it
- A systematic review and meta-analysis of the mental health symptoms during the Covid-19 pandemic in Southeast Asia.Psychiatry and clinical neurosciences · 2022Pooled it
- Clinical Utility of Functional Near-Infrared Spectroscopy for Assessment and Prediction of Suicidality: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Effects of theta burst stimulation on cognitive function and characteristics of blood oxygen alterations based on near-infrared spectroscopy in chronic schizophrenia.BMC psychiatry · 2025Trial
- Neural correlates of fine motor grasping skills: Longitudinal insights into motor cortex activation using fNIRS.Brain and behavior · 2024Trial
- Brief Relaxation Practice Induces Significantly More Prefrontal Cortex Activation during Arithmetic Tasks Comparing to Viewing Greenery Images as Revealed by Functional Near-Infrared Spectroscopy (fNIRS).International journal of environmental research and public health · 2020Trial
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- A High-Accuracy and Easy-Use Differential Diagnosis Method of Bipolar Disorder Depressive Phase and Major Depressive Disorder Using a Wearable Near-Infrared Spectroscopy.Bipolar disorders · 2026Article
- Toward a visualized classifier for depression: characterization of hemodynamic patterns using time-domain fNIRS.Frontiers in psychiatry · 2026Article
- [Analysis of the relationship between acute stress disorder or posttraumatic stress disorder and total burn area in adult burn patients based on brain function detection results].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- The Clinical Utility of Biomarkers in Diagnosing Major Depressive Disorder in Adults: A Systematic Review of Literature From 2013 to 2023.Psychiatry investigation · 2025Article
- Application of functional near-infrared spectroscopy and machine learning to predict treatment response after six months in major depressive disorder.Translational psychiatry · 2025Article
- Near-infrared brain imaging study of depressive disorder with liver qi stagnation syndrome before and after treatment.Frontiers in psychiatry · 2025Article
- Assessment of Brain Function After 240 Days Confinement Using Functional Near Infrared Spectroscopy.IEEE open journal of engineering in medicine and biology · 2025Article
- fNIRS evidence of abnormal frontotemporal cortex activation and functional connectivity in depressed patients after stroke: neuromodulatory mechanisms from mild to moderate depression.Frontiers in neurology · 2025Article
- Cortical activation during the verbal fluency task for obstructive sleep apnea patients with depressive symptoms: A multi-channel fNIRS study.Brain and behavior · 2024Article
- Cortical activation for adolescent-onset minor depression and major depressive disorder: an fNIRS study.Annals of general psychiatry · 2024Article
- Research in China about the biological mechanisms that potentially link socioenvironmental changes and mental health: a scoping review.The Lancet regional health. Western Pacific · 2024Article
- A free association semantic task for fNIRS-based perinatal depression assessment.Frontiers in neurology · 2024Article
- Pilot Study of Cerebral Hemodynamics in Depressive Patient Under Electroconvulsive Therapy.Neuropsychiatric disease and treatment · 2024Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced haemodynamic response in the frontotemporal cortices of patients with major depressive disorder (MDD) has been demonstrated using functional near-infrared spectroscopy (fNIRS). Most notably, changes in cortical oxy-haemoglobin during a Japanese phonetic fluency task can differentiate psychiatric patients from healthy controls (HC). However, this paradigm has not been validated in the English language. Therefore, the present work aimed to distinguish patients with MDD from HCs, using haemodynamic response measured during an English letter fluency task. One hundred and five HCs and 105 patients with MDD took part in this study. NIRS signals during the verbal fluency task (VFT) was acquired using a 52-channel system, and changes in oxy-haemoglobin in the frontal and temporal regions were quantified. Depression severity, psychosocial functioning, pharmacotherapy and psychiatric history were noted. Patients with MDD had smaller changes in oxy-haemoglobin in the frontal and temporal cortices than HCs. In both regions of interest, oxy-haemoglobin was not associated with any of the clinical variables studied. 75.2% and 76.5% of patients with MDD were correctly classified using frontal and temporal region oxy-haemoglobin, respectively. Haemodynamic response measured by fNIRS during an English letter fluency task is a promising biomarker for MDD.
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