Evidence map›Paper›PMID 32546688›Full record

ArticleNature communications2020

Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface.

Srinivas Abbina, Lily E Takeuchi, Parambath Anilkumar, Kai Yu, Jason C Rogalski, Rajesh A Shenoi, Iren Constantinescu, Jayachandran N Kizhakkedathu

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Srinivas Abbina *Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.ORCID http://orcid.org/0000-0002-9103-7444
Lily E Takeuchi *Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Parambath Anilkumar *Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.ORCID http://orcid.org/0000-0003-4898-0565
Kai YuCentre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Jason C RogalskiCentre for High Throughput Biology, Michael Smith Laboratories, The University of British Columbia, Vancouver, BC, V6T 1Z1, Canada.
Rajesh A ShenoiInter University Centre for Biomedical Research & Super Speciality Hospital, Mahatma Gandhi University Campus at Thalappady, Rubber Board P O, Kottayam, Kerala, 686 009, India.
Iren ConstantinescuCentre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Jayachandran N KizhakkedathuCentre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. jay@pathology.ubc.ca.ORCID http://orcid.org/0000-0001-7688-7574

Funding

CIHR
6 · The paper itself

Abstract

Nanomaterials in the blood must mitigate the immune response to have a prolonged vascular residency in vivo. The composition of the protein corona that forms at the nano-biointerface may be directing this, however, the possible correlation of corona composition with blood residency is currently unknown. Here' we report a panel of new soft single molecule polymer nanomaterials (SMPNs) with varying circulation times in mice (t

Indexed as

Administration, IntravenousAnimalsBiocompatible MaterialsBlood CirculationFemaleHalf-LifeHumansMaleMice, Inbred BALB CNanostructuresOpsonin ProteinsPolymersProtein CoronaTandem Mass SpectrometryTissue DistributionBiocompatible MaterialsOpsonin ProteinsPolymersProtein Corona

Identifiers

PMID32546688
PMCPMC7298025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.