Evidence map›Paper›PMID 32546622›Full record

ArticlemBio2020

Risk1, a Phosphatidylinositol 3-Kinase Effector, Promotes Rickettsia typhi Intracellular Survival.

Oliver H Voss, Joseph J Gillespie, Stephanie S Lehman, Sherri A Rennoll, Magda Beier-Sexton, M Sayeedur Rahman, Abdu F Azad

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Hybrid capture RNA-seq defines temporal gene expression inbioRxiv : the preprint server for biology · 2026
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  5. Mitochondrial Dysfunction inTransboundary and emerging diseases · 2026
    Review
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  11. Review
  12. Article
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  14. Cat Flea Coinfection withVector borne and zoonotic diseases (Larchmont, N.Y.) · 2024
    Article
  15. PathogenicJournal of bacteriology · 2024
    Review
  16. mSphere · 2023
    Article
  17. Article
  18. Review
  19. bioRxiv : the preprint server for biology · 2023
    Article
  20. Metagenome diversity illuminates origins of pathogen effectors.bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Oliver H VossDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA ovoss@som.umaryland.edu aazad@som.umaryland.edu.
Joseph J GillespieDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Stephanie S LehmanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sherri A RennollDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Magda Beier-SextonDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
M Sayeedur RahmanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Abdu F AzadDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA ovoss@som.umaryland.edu aazad@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSIONR01AI017828 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAHMAN, MOHAMMED SAYEEDUR · 1985 to 2022
$10.2M
Rickettsia-host interface and multiple paths to invasionR01AI126853 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Mohammed Sayeedur Rahman, Oliver Voss · 2016 to 2026
$6.9M
Rickettsia cell envelope glycoconjugates are derived from the host cell amino sugar biosynthesis pathwayR21AI146773 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J, RAHMAN, MOHAMMED SAYEEDUR · 2019 to 2020
$425k
NIAID NIH HHS R01 AI017828NIAID NIH HHS R01 AI126853NIAID NIH HHS R21 AI146773
6 · The paper itself

Abstract

To establish a habitable intracellular niche, various pathogenic bacteria secrete effectors that target intracellular trafficking and modulate phosphoinositide (PI) metabolism. Murine typhus, caused by the obligate intracellular bacterium

Indexed as

AnimalsBacterial ProteinsChlorocebus aethiopsEndosomesHeLa CellsHumansIntracellular SpaceMicePhagosomesPhosphatidylinositol 3-KinasePhosphatidylinositolsRickettsia typhiSignal TransductionVero CellsBacterial ProteinsPhosphatidylinositol 3-KinasePhosphatidylinositolsautophagosomal maturationbacterial escapeBeclin-1EEA1endosomal traffickingLC3bphagosome escapephosphoinositide metabolismRab5Risk1R. typhiubiquitin

Identifiers

PMID32546622
PMCPMC7298712
OpenAlexW3035400674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.