Evidence map›Paper›PMID 32546613›Full record

ArticlemBio2020

Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures.

Hervé Cassard, Alvina Huor, Juan-Carlos Espinosa, Jean-Yves Douet, Severine Lugan, Naima Aron, Didier Vilette, Marie-Bernadette Delisle, Alba Marín-Moreno, Patrice Peran and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Creutzfeldt-Jakob disease and other prion diseases.Nature reviews. Disease primers · 2024
    Review
  9. Multiple aspects of amyloid dynamicsFrontiers in molecular neuroscience · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. MetNeuropathology and applied neurobiology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Hervé Cassard *UMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France.
Alvina Huor *UMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France.
Juan-Carlos Espinosa *Centro de Investigación en Sanidad Animal (INIA-CISA), Valdeolmos, Madrid, Spain.ORCID 0000-0002-6719-9902
Jean-Yves DouetUMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France.
Severine LuganUMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France.
Naima AronUMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France.
Didier ViletteUMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France.
Marie-Bernadette DelisleINSERM U 1214 TONIC, CHU Purpan, Toulouse, France.
Alba Marín-MorenoCentro de Investigación en Sanidad Animal (INIA-CISA), Valdeolmos, Madrid, Spain.
Patrice PeranINSERM U 1214 TONIC, CHU Purpan, Toulouse, France.
Vincent BeringueVirologie et Immunologie Moléculaires, Domaine de Vilvert, Jouy-en-Josas, France.ORCID 0000-0001-6706-5712
Juan Maria TorresCentro de Investigación en Sanidad Animal (INIA-CISA), Valdeolmos, Madrid, Spain.
James W IronsideNational Creutzfeldt-Jakob Disease Research & Surveillance Unit, Centre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Olivier AndreolettiUMR INRA ENVT 1225, Interactions Hôte Agent Pathogène, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France o.andreoletti@envt.fr.
École Nationale Vétérinaire de Toulouse · FRCentre de Recerca en Sanitat Animal · ESInserm · FRVirologie et Immunologie Moléculaires · FRWestern General Hospital · GB

Funding

Medical Research Council G0900580
6 · The paper itself

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently classified according to the methionine/valine polymorphism at codon 129 of the

Indexed as

Genetic VariationAnimalsBiological AssayBrainCell LineCodonCreutzfeldt-Jakob SyndromeFemaleHumansMethionineMicePrionsProtein IsoformsPrPSc ProteinsValineCodonMethioninePrionsProtein IsoformsPrPSc ProteinsValinediversityevolutionprionprionssCJDsporadic Creutzfeldt-Jakob diseasestrain diversitystrains

Identifiers

PMID32546613
PMCPMC7298703
OpenAlexW3034798269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.