ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020
Genome-Wide Gene-Diabetes and Gene-Obesity Interaction Scan in 8,255 Cases and 11,900 Controls from PanScan and PanC4 Consortia.
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Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Polygenic scores capture genetic modification of the adiposity-cardiometabolic risk factor relationship.Cell genomics · 2026Article
- Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Expanding the Scope: In-depth Review of Interaction in Regression Models.Annals of clinical epidemiology · 2024Article
- Identification of novel susceptibility methylation loci for pancreatic cancer in a two-phase epigenome-wide association study.Epigenetics · 2022Article
- Overexpression of OAS1 Is Correlated With Poor Prognosis in Pancreatic Cancer.Frontiers in oncology · 2022Article
- A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer.Genome medicine · 2021Article
- Three Immune-Related Prognostic mRNAs as Therapeutic Targets for Pancreatic Cancer.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
71 authors at 20 institutions in 12 countries.
Hongwei Tang *Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Lai Jiang *Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Rachael Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Alan A ArslanDepartment of Obstetrics and Gynecology, New York University School of Medicine, New York, New York.ORCID 0000-0002-7775-8085
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-0518-8714
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-4261-4583
Mengmeng DuDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.
Graham G GilesDivision of Cancer Epidemiology, Cancer Council Victoria, Melbourne, Victoria, Australia.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Loïc Le MarchandCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Rachel E NealePopulation Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Emily WhiteCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Ana BabicDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
William R BamletDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2903-1284
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Amanda BlackfordDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-6519-4833
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Julie E BuringDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Daniele CampaDepartment of Biology, University of Pisa, Pisa, Italy.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Erica ChildsDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Eric J DuellOncology Data Analytics Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0001-5256-0163
Charles FuchsYale Cancer Center, New Haven, Connecticut.
J Michael GazianoDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Michael GogginsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Manal H HassamDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Robert N HooverDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-4486-7496
Robert C KurtzGastroenterology, Hepatology, and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, New York.
I-Min LeeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Núria MalatsGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre, Madrid, Spain.ORCID 0000-0003-2538-3784
Roger L MilneDivision of Cancer Epidemiology, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0001-5764-7268
Kimmie NgDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Ann L ObergDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2539-9807
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-6234-6961
Ulrike PetersCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Miquel PortaCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Kari G RabeDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Ghislaine SceloInternational Agency for Research on Cancer, Lyon, France.
Howard D SessoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0002-9698-9954
Debra T SilvermanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Ian M ThompsonCHRISTUS Santa Rosa Hospital - Medical Center, San Antonio, Texas.
Anne TjønnelandDepartment of Public Health, University of Copenhagen and Danish Cancer Society Research Center Diet, Genes and Environment, Copenhagen, Denmark.ORCID 0000-0003-4385-2097
Antonia TrichopoulouHellenic Health Foundation, World Health Organization Collaborating Center of Nutrition, Medical School, University of Athens, Athens, Greece.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University of Buffalo, Buffalo, New York.ORCID 0000-0003-3096-9595
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Herbert YuCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.ORCID 0000-0003-3950-4815
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, New York.
Laufey T AmundadottirDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.ORCID 0000-0003-1859-8971
Eric J JacobsDepartment of Public Health, University of Copenhagen and Danish Cancer Society Research Center Diet, Genes and Environment, Copenhagen, Denmark.
Gloria M PetersenDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.
Brian M WolpinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Nilanjan ChatterjeeDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Alison P KleinDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0003-2737-8399
Donghui Li *Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. pwei2@mdanderson.org pkraft@hsph.harvard.edu dli@mdanderson.org.ORCID 0000-0002-7542-0662
Peter Kraft *Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. pwei2@mdanderson.org pkraft@hsph.harvard.edu dli@mdanderson.org.
Peng Wei *Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas. pwei2@mdanderson.org pkraft@hsph.harvard.edu dli@mdanderson.org.
Center for Cancer Research · USJohns Hopkins University · USBrigham and Women's Hospital · USFred Hutch Cancer Center · USMayo Clinic · USThe University of Texas MD Anderson Cancer Center · USCancer Center of Hawaii · USDana-Farber Cancer Institute · USMemorial Sloan Kettering Cancer Center · USCentre international de recherche sur le cancer · FRDanish Cancer Society · DKHarvard University · USLunenfeld-Tanenbaum Research Institute · CANew York University · USThe University of Melbourne · AUUniversity of California, San Francisco · USVanderbilt University · USBellvitge University Hospital · ESChristus Santa Rosa Health System · USGerman Cancer Research Center · DE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MTumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MTranslational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Pallav Pokhrel · 1996 to 2026
$56.2MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI THOMPSON, ELIZABETH D · 1993 to 2022
$54.6MTissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2018
$32.7MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MRESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1MNCI NIH HHS P01 CA087969NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA102701NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA097075NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA098870NCI NIH HHS R01 CA102765NCI NIH HHS R01 CA109767NCI NIH HHS R01 CA154823NCI NIH HHS R01 CA169122NCI NIH HHS R03 CA123546NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA182934NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974NCI NIH HHS UH2 CA191284NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182910NCI NIH HHS UM1 CA182934NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS RC1 HL099355NIEHS NIH HHS P30 ES000260World Health Organization 001
Abstract
backgroundObesity and diabetes are major modifiable risk factors for pancreatic cancer. Interactions between genetic variants and diabetes/obesity have not previously been comprehensively investigated in pancreatic cancer at the genome-wide level.
methodsWe conducted a gene-environment interaction (GxE) analysis including 8,255 cases and 11,900 controls from four pancreatic cancer genome-wide association study (GWAS) datasets (Pancreatic Cancer Cohort Consortium I-III and Pancreatic Cancer Case Control Consortium). Obesity (body mass index ≥30 kg/m
resultsNo genome-wide significant interactions (departures from a log-additive odds model) with diabetes or obesity were detected at the SNP level by the CC or CO approaches. The joint-effect test detected numerous genome-wide significant GxE signals in the GWAS main effects top hit regions, but the significance diminished after adjusting for the GWAS top hits. In the gene-based analysis, a significant interaction of diabetes with variants in the
conclusionsThis analysis did not find significant GxE interactions at the SNP level but found one significant interaction with diabetes at the gene level. A larger sample size might unveil additional genetic factors via GxE scans. IMPACT: This study may contribute to discovering the mechanism of diabetes-associated pancreatic cancer.
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Case-Control StudiesDiabetes MellitusFemaleGenome-Wide Association StudyHumansMaleObesityRisk Factors
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