ArticleJournal of the American Society of Nephrology : JASN2020
Estimation of Intraglomerular Pressure Using Invasive Renal Arterial Pressure and Flow Velocity Measurements in Humans.
Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Determinants of renal flow reserve in adult patients with and without renal artery stenosis.Physiological reports · 2025Article
- Clinical Trial: Effects of Autologous Dendritic Cell Administration on Renal Hemodynamics and Inflammatory Biomarkers in Diabetic Kidney Disease.Diseases (Basel, Switzerland) · 2025Article
- Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis.BMC cardiovascular disorders · 2025Article
- Development and Internal Validation of a Nomogram for Predicting Acute Kidney Injury After Cardiac Valve Surgery Using the Serum Uric Acid-to-Albumin Ratio.Journal of inflammation research · 2025Article
- Role of biophysics and mechanobiology in podocyte physiology.Nature reviews. Nephrology · 2024Review
- Impaired Renal Vein Flow in Atrial Fibrillation: A Potential Risk for Renal Dysfunction.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Oscillometric pulse wave analysis for detecting low flow arteriovenous fistula.BMC nephrology · 2023Article
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Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlomerular hyperfiltration resulting from an elevated intraglomerular pressure (Pglom) is an important cause of CKD, but there is no feasible method to directly assess Pglom in humans. We developed a model to estimate Pglom in patients from combined renal arterial pressure and flow measurements.
methodsWe performed hemodynamic measurements in 34 patients undergoing renal or cardiac angiography under baseline conditions and during hyperemia induced by intrarenal dopamine infusion (30
resultsWe successfully analyzed data from 28 (82%) patients. Median age was 58 years (IQR, 52-65), median eGFR was 95 ml/min per 1.73 m
conclusionsWe constructed a model on the basis of proximal renal arterial pressure and flow velocity measurements that provides an overall estimate of glomerular pressure and afferent and efferent resistance in humans. The model provides a novel research technique to evaluate the hemodynamics of CKD on the basis of direct pressure and flow measurements. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Functional HEmodynamics in patients with and without Renal Artery stenosis (HERA), NL40795.018.12 at the Dutch national trial registry (toetsingonline.nl).
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