Evidence map›Paper›PMID 32546275›Full record

ArticleLipids in health and disease2020

Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults.

Kamalita Pertiwi, Leanne K Küpers, Johanna M Geleijnse, Peter L Zock, Anne J Wanders, Herculina S Kruger, Tertia van Zyl, Iolanthé M Kruger, Cornelius M Smuts

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03225586 (Prospective Urban Rural Epidemiology Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03225586 recruitingnot on this map

Prospective Urban Rural Epidemiology Study

TypeobservationalSponsorPopulation Health Research InstituteRan2002 to 2030Enrolled200,000ConditionsCardiovascular Diseases, Risk Factor, Cardiovascular, Health Behavior, Environmental Exposure
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kamalita PertiwiDivision of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands. kamalita.pertiwi@wur.nl.ORCID http://orcid.org/0000-0003-2861-9051
Leanne K KüpersDivision of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Johanna M GeleijnseDivision of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Peter L ZockDivision of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Anne J WandersUnilever R&D, Foods Innovation Centre, Wageningen, the Netherlands.
Herculina S KrugerCentre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Tertia van ZylCentre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Iolanthé M KrugerAfrica Unit for Transdisciplinary Health Research, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Cornelius M SmutsCentre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
North-West University · ZAWageningen University & Research · NLUnilever Foods Innovation Centre · NL

Funding

South African National Research Foundation NRF GUN numbers 2069139 and FA2006040700010; FA2007042600011
6 · The paper itself

Abstract

backgroundThe relation between dietary and circulating linoleic acid (18:2 n-6, LA), glucose metabolism and liver function is not yet clear. Associations of dietary and circulating LA with glucose metabolism and liver function markers were investigated.

methodsCross-sectional analyses in 633 black South Africans (aged > 30 years, 62% female, 51% urban) without type 2 diabetes at baseline of the Prospective Urban Rural Epidemiology study. A cultural-sensitive 145-item food-frequency questionnaire was used to collect dietary data, including LA (percentage of energy; en%). Blood samples were collected to measure circulating LA (% total fatty acids (FA); plasma phospholipids), plasma glucose, glycosylated hemoglobin (HbA1c), serum gamma-glutamyl transferase (GGT), alanine (ALT) and aspartate aminotransferase (AST). Associations per 1 standard deviation (SD) and in tertiles were analyzed using multivariable regression.

resultsMean (±SD) dietary and circulating LA was 6.8 (±3.1) en% and 16.0 (±3.5) % total FA, respectively. Dietary and circulating LA were not associated with plasma glucose or HbA1c (β per 1 SD: - 0.005 to 0.010, P > 0.20). Higher dietary LA was generally associated with lower serum liver enzymes levels. One SD higher circulating LA was associated with 22% lower serum GGT (β (95% confidence interval): - 0.25 (- 0.31, - 0.18), P < 0.001), but only ≤9% lower for ALT and AST. Circulating LA and serum GGT associations differed by alcohol use and locality.

conclusionDietary and circulating LA were inversely associated with markers of impaired liver function, but not with glucose metabolism. Alcohol use may play a role in the association between LA and liver function.

trial registrationPURE North-West Province South Africa study described in this manuscript is part of the PURE study. The PURE study is registered in ClinicalTrials.gov (Identifier: NCT03225586; URL).

Indexed as

AdultAgedBiomarkersBlack PeopleFemalegamma-GlutamyltransferaseGlucoseGlycated HemoglobinHumansLinoleic AcidLiverLiver DiseasesMaleMiddle AgedPhospholipidsSouth AfricaBiomarkersgamma-GlutamyltransferaseGlucoseGlycated HemoglobinLinoleic AcidPhospholipidsAfricanAlcohol intakeGamma-glutamyl transferaseGlycemiaLinoleic acidLiver enzymesPolyunsaturated fatty acids

Identifiers

PMID32546275
PMCPMC7296762
OpenAlexW3035177494

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.