ArticleLipids in health and disease2020
Association between apolipoprotein E gene polymorphism and the risk of coronary artery disease in Hakka postmenopausal women in southern China.
Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Correlation between ApoE gene polymorphisms and the prognosis of coronary artery disease in patients undergoing percutaneous coronary intervention.BMC cardiovascular disorders · 2025Article
- Influence of apolipoprotein E gene polymorphisms on coronary artery disease in patients undergoing coronary angiography.Heliyon · 2024Article
- Sex-specific differences in the association between APOE genotype and metabolic syndrome among middle-aged and older rural Indians.Metabolism open · 2024Article
- Association ofGenes · 2023Article
- Article
- Association of Apolipoprotein E Gene Polymorphism with Type 2 Diabetic Nephropathy in the Southern Chinese Population.International journal of general medicine · 2023Article
- Effect of Apolipoprotein E ε4 Allele on the Progression of Carotid Atherosclerosis Through Apolipoprotein Levels.Pharmacogenomics and personalized medicine · 2022Article
- Plasma Proteome Profiling of Patients With In-stent Restenosis by Tandem Mass Tag-Based Quantitative Proteomics Approach.Frontiers in cardiovascular medicine · 2022Article
- Association between apolipoprotein E gene polymorphism and nonalcoholic fatty liver disease in Southern China: A case-control study.Journal of clinical laboratory analysis · 2021Article
- Association between the APOE gene polymorphism and lipid profile and the risk of atrial fibrillation.Lipids in health and disease · 2021Article
- Apolipoprotein E Gene Polymorphism and Coronary Artery Disease Risk Among Patients in Northwest China.Pharmacogenomics and personalized medicine · 2021Article
- Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population.International journal of general medicine · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundApolipoprotein E (APOE) is involved in the pathogenesis of atherosclerosis and conveys a higher risk of coronary artery disease (CAD). The aim of the present study was to investigate the possible association between APOE gene polymorphism and the risk of CAD in postmenopausal Hakka women in southern China.
methodsThe APOE genotypes of 653 CAD patients and 646 control participants were determined by the polymerase chain reaction (PCR) and hybridization to a Sinochip.
resultsThe prevalence of each APOE genotype differed between CAD patients and control participants (P = 0.011). The E3/E3 genotype was the most common and the E2/E2 genotype was the least common in the study sample. Moreover, the presence of ε4 allele was associated with higher serum concentrations of triglycerides (TG), total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C), and lower concentration of high-density lipoprotein-cholesterol (HDL-C). Multiple logistic regression analysis revealed that participants with ε4 allele have a significantly higher risk of CAD after adjustment for the presence of diabetes mellitus and hypertension, and their serum uric acid, TC, and LDL-C concentrations (adjusted odds ratio (OR) 1.50, 95% confidence interval (CI) 1.10-2.05, P = 0.010).
conclusionsThe present results suggest that APOE polymorphism is associated with a higher risk of CAD in postmenopausal Hakka women in southern China.
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