ArticleLipids in health and disease2020
Associations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition Survey.
Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Essential Trace Elements in Patients with Dyslipidemia: A Meta-analysis.Current medicinal chemistry · 2024Pooled it
- Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of cardiometabolic diseases: Unraveling the mediating role of inflammatory markers.Eco-Environment & Health · 2026Article
- Urinary Ferritin: A Non-inflammatory Iron Marker Linked to Insulin Resistance and Metabolic Syndrome Components.Journal of obesity & metabolic syndrome · 2026Article
- Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects.Signal transduction and targeted therapy · 2024Review
- Associations of dietary iron intake with cardiovascular disease risk and dyslipidemia among Chinese adults.Lipids in health and disease · 2024Article
- Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis.Scientific reports · 2024Article
- The association between lipid profile, oxidized LDL and the components of metabolic syndrome with serum mineral status and kidney function in individuals with obesity.BMC research notes · 2023Article
- Article
- Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents.International journal of environmental research and public health · 2022Article
- Combined Associations of Serum Ferritin and Body Size Phenotypes With Cardiovascular Risk Profiles: A Chinese Population-Based Study.Frontiers in public health · 2021Article
- Effects of Dietary Glucose and Fructose on Copper, Iron, and Zinc Metabolism Parameters in Humans.Nutrients · 2020Article
- Responses of Intestinal Microbiota and Immunity to Increasing Dietary Levels of Iron Using a Piglet Model.Frontiers in cell and developmental biology · 2020Article
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Abstract
backgroundIron overload has been found to be related with various cardiometabolic disorders, like dyslipidemia, metabolic syndrome, and diabetes. The disturbance of the iron status and lipid metabolism can contribute to organ damage such as atherosclerotic plaque growth and instability. An assessment on the associations of iron status with apolipoproteins and lipid ratios would be informative for maintenance of metabolic homeostasis and hinderance of disease progression. Hence, this study aims to establish the relationships of iron status with apolipoproteins and lipid ratios.
methodsA cross-sectional study of 7540 adult participants from the China Health and Nutrition Survey 2009 was conducted. Logistic regression analyses were used to investigate the relationships between indicators of iron status and the prevalence of unfavorable apolipoprotein profiles. Multivariate linear regression models were constructed to assess the dose-response correlations between serum ferritin and lipid parameters.
resultsAfter adjustment for confounding factors, in both sexes, the subjects in the top quartile of ferritin had the highest prevalence of an elevated apolipoprotein B (men: odds ratio (OR) 1.97, 95% confidence interval (CI) 1.50-2.62; women: OR 2.13, 95% CI 1.53-2.97) and an elevated apolipoprotein B/apolipoprotein A1 ratio (men: OR 2.00, 95% CI 1.50-2.66; women: OR 1.41, 95% CI 1.04-1.92) when compared with individuals in the lowest quartile. Hemoglobin were also independently associated with unfavorable apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio both in men and women. However, transferrin (men: OR 0.74, 95% CI 0.56-0.99; women: OR 0.73, 95% CI 0.56-0.95) and soluble transferrin receptor (men: OR 0.75, 95% CI 0.57-0.99; women: OR 0.71, 95% CI 0.55-0.91) were found to be negatively associated with a decreased apolipoprotein A1. Moreover, after controlling for potential confounders, the ferritin concentrations were significantly associated with the levels of lipid ratios including TG/HDL-C, non-HDL-C/HDL-C, TC/HDL-C, apoB/apoA1, and LDL-C/HDL-C ratio in men (β coefficient = 0.147, 0.061, 0.043, 0.038, 0.032, respectively, all P values < 0.001) and in women (β coefficient = 0.074, 0.034, 0.025, 0.020, 0.018, respectively, all P values < 0.05).
conclusionsThe indicators of iron status are significantly associated with unfavorable apolipoprotein profiles. Serum ferritin concentrations are positively correlated with the levels of lipid ratios. The management on the modifiable iron status and lipid metabolism has a clinical significance. The atherosclerotic lipid profiles of the patients with iron overload deserve special clinical concerns.
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