ArticleRespiratory research2020
The impact of adjuvant surgical treatment of nontuberculous mycobacterial pulmonary disease on prognosis and outcome.
Article in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Early surgical intervention for extensive nontuberculous mycobacterial pulmonary disease.IJTLD open · 2025Article
- Three-dimensional imaging assisted segmentectomy in the treatment of localized bronchiectasis: a retrospective analysis.Journal of cardiothoracic surgery · 2025Article
- MGIT-seq for the Identification of Nontuberculous Mycobacteria and Drug Resistance: a Prospective Study.Journal of clinical microbiology · 2023Article
- IgA Serological Response for the Diagnosis of Mycobacterium abscessus Infections in Patients with Cystic Fibrosis.Microbiology spectrum · 2022Article
- Pulmonary cavitary disease due toInfectious medicine · 2022Article
- Non-tuberculous mycobacteria pulmonary disease: A review of trends, risk factors, diagnosis and management.African journal of thoracic and critical care medicine · 2022Review
- Outcomes of adjunctive surgery for nontuberculous mycobacterial pulmonary disease.BMC pulmonary medicine · 2021Article
- New/Different Look at the Presence ofMicroorganisms · 2021Article
- First line treatment selection modifies disease course and long-term clinical outcomes in Mycobacterium avium complex pulmonary disease.Scientific reports · 2021Article
- Adjuvant surgical resection for nontuberculous mycobacterial pulmonary disease: Effectiveness and complications.Annals of thoracic medicineArticle
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Authors and funding
19 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has been reported to be associated with favorable outcomes. However, little is known regarding the risk and prognostic factors for refractory and recurrent cases. We aimed to evaluate the overall impact and benefit of adjuvant lung surgery by comparing NTM-PD patients who underwent adjuvant lung resection with those treated exclusively with antibiotics. We also investigated the efficacy of serum IgA antibody against glycopeptidolipid (GPL) core antigen (GPL core antibody) to monitor disease activity and predict the recurrence of disease after adjuvant lung resection.
methodsWe retrospectively evaluated the clinical characteristics and surgical outcomes of 35 patients surgically treated for NTM-PD. Furthermore, we compared surgically treated patients and control patients treated exclusively with antibiotics who were matched statistically 1:1 using a propensity score calculated from age, sex, body mass index, and radiologic features of disease.
resultsIn the surgically treated patients, the median age was 58 (interquartile range, 47-65) years and 65.7% were female. Twenty-eight patients had Mycobacterium avium complex. Operations comprised four pneumonectomies, two bilobectomies, one bilobectomy plus segmentectomy, 17 lobectomies, two segmentectomies, and nine lobectomies plus segmentectomies. Postoperative complications occurred in seven patients (20%), there were no operative deaths, and 33 (94.3%) patients achieved negative sputum culture conversion. Refractory and recurrent cases were associated with remnant bronchiectasis, contralateral shadows, and positive acid-fast bacilli staining or culture. Of 28 statistically matched pairs, long-term sustained negative culture conversion was observed in 23 (82.2%) surgical group patients and in 14 (50.0%) non-surgical group patients (0.0438). The mortality rate was lower in the surgical group, but did not reach statistical significance (one in the surgical group and four in the non-surgical group, p = 0.3516). GPL core antibody was correlated with disease activity and recurrence.
conclusionsNTM-PD patients who underwent adjuvant lung resection experienced overall favorable outcomes and achieved sputum culture conversion more frequently. Long-term mortality may have been reduced by this procedure, and the level of GPL core antibody was shown to be a good clinical indicator of disease activity after surgery.
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