ArticleBMC infectious diseases2020
Human adenovirus Coinfection aggravates the severity of Mycoplasma pneumoniae pneumonia in children.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Continuous Positive Airway Pressure (CPAP) for severe pneumonia in low- and middle-income countries: A systematic review of contextual factors.Journal of global health · 2022Pooled it
- Coinfection Patterns ofInternational journal of molecular sciences · 2026Article
- Clinical characteristics and predictors of Mycoplasma pneumoniae pneumonia coinfection with Bordetella pertussis in children.Medicine · 2026Article
- Viral-bacterial codetection and clinical and laboratory characteristics in children hospitalized with lower respiratory tract infections in a private hospital in Lima, Peru: a cross-sectional study.Tropical diseases, travel medicine and vaccines · 2026Article
- Impact of pathogen co-detection on disease severity and clinical outcomes in children with Mycoplasma pneumoniae pneumonia.World journal of pediatrics : WJP · 2026Article
- Clinical utility of the targeted next-generation sequencing for detection of Mycoplasma pneumoniae and antimicrobial resistance genes for adults.BMC infectious diseases · 2026Article
- Post-pandemic resurgence of Mycoplasma pneumoniae in coastal China: from seasonal waves to sustained transmission and expanded age susceptibility.BMC infectious diseases · 2026Article
- Molecular epidemiology and clinical characteristics of human adenovirus in children in Hangzhou (2022-2023).Archives of virology · 2026Article
- Host inflammatory markers and MLVA profiling for risk assessment of severe pediatricFrontiers in cellular and infection microbiology · 2026Article
- Beyond the usual suspects: Unveiling adenovirus-mycoplasma coinfection in severe paediatric pneumonia-A case series.Lung India : official organ of Indian Chest Society · 2026Article
- Targeted next-generation sequencing analysis of pathogens and microecology in pediatric lower respiratory tract infections identifies risk factors for severe community-acquired pneumonia.Frontiers in cellular and infection microbiology · 2026Article
- Multi-omics analysis of host airway responses in pediatric Mycoplasma pneumoniae pneumonia reveals potential mechanisms of disease exacerbation caused by co-infection.NPJ biofilms and microbiomes · 2025Article
- Clinical analysis of Mycoplasma pneumoniae pneumonia combined with adenovirus infection in children with lobar pneumonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Co-Detection of ADV, Influenza B, and HPIV: Independent Risk Factors for SMPP with Changes in NPIs.Viruses · 2025Article
- Characteristics and risk factors for outcomes in patients withInfectious Disease Modelling · 2025Article
- Changes in the epidemic patterns of respiratory pathogens of children in guangzhou, China during the COVID-19 pandemic.BMC infectious diseases · 2025Article
- Association of human adenovirus load and viral genotype diversity with respiratory disease severity in children: a systematic review and meta-analysis.Translational pediatrics · 2025Article
- Clinical characteristics of severe community-acquired pneumonia in children with virus mono-detection versus co-detection with bacteria.BMC pulmonary medicine · 2025Article
- Analysis of the characteristics of mixed infections with Mycoplasma pneumoniae in children.Scientific reports · 2025Article
- The virome composition of respiratory tract changes in school-aged children with Mycoplasma pneumoniae infection.Virology journal · 2025Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMycoplasma pneumoniae (M. pneumoniae) is an important pathogen of community-acquired pneumonia (CAP) in children. The coinfection rate of M. pneumoniae pneumonia (MPP) can reach 52% in some areas, but the effects of coinfection with different pathogens have not been clearly recognized.
methodsThe cases of MPP hospitalized in Beijing Children's Hospital from 1/1/2014 to 12/31/2016 were screened. MPP patients coinfected with Human adenovirus (HAdV) were categorized into the research group. Patients with single M. pneumoniae infection were categorized into the control group, matching the research group by age and admission time with a ratio of 1:3. Clinical manifestations, laboratory examinations, and disease severity were compared between these two groups.
resultsA total of 2540 hospitalized MPP cases were screened in Beijing Children's Hospital, among which thirty cases were enrolled in the research group and ninety cases were enrolled in the control group. The results indicated that patients in the research group had longer hospital stays, longer fever durations and a higher rate of dyspnea, as well as a larger proportion applications of oxygen therapy and noninvasive continuous positive airway pressure (NCPAP). No obvious differences were found in lab examinations within the two groups. Regarding disease severity, the proportions of extremely severe pneumonia and severe disease defined by the clinical score system were higher in the research group than in the control group.
conclusionCompared with single M. pneumoniae infection, MPP coinfected with HAdV in children was relatively more serious.
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