ArticleLangmuir : the ACS journal of surfaces and colloids2020
Label-Free Sensitive Detection of Steroid Hormone Cortisol Based on Target-Induced Fluorescence Quenching of Quantum Dots.
Article in Langmuir : the ACS journal of surfaces and colloids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- Advances in salivary cortisol monitoring for healthcare applications.RSC advances · 2026Review
- A quantitative, multimodal wearable bioelectronic device for comprehensive stress assessment and sub-classification.Nature communications · 2026Article
- Optimized hexamine-derived carbonized polymer dots as fluorescent nanoswitches for precision spectral imaging sensing of glucocorticoids.Mikrochimica acta · 2026Article
- Development of Molecularly Imprinted Conducting Polymers for Stress Biomarker Cortisol Detection.ACS applied polymer materials · 2025Article
- Stimuli-responsive smart materials enabled high-performance biosensors for liquid biopsies.Journal of nanobiotechnology · 2025Review
- Recent Advances on Rapid Detection Methods of Steroid Hormones in Animal Origin Foods.Biosensors · 2025Review
- Article
- Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring.ACS sensors · 2024Review
- Clinical Endocrinology-Time for a Reset?Journal of the Endocrine Society · 2024Article
- Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods.Biosensors · 2023Review
- Cortisol Monitoring Devices toward Implementation for Clinically Relevant Biosensing In Vivo.Molecules (Basel, Switzerland) · 2023Review
- Cortisol Immunosensors: A Literature Review.Biosensors · 2023Review
- A "Two-Part" Resonance Circuit Based Detachable Sweat Patch for Noninvasive Biochemical and Biophysical Sensing.Advanced functional materials · 2023Article
- Nanomaterials for Cortisol Sensing.Nanomaterials (Basel, Switzerland) · 2022Review
- New Trends in Fluorescent Nanomaterials-Based Bio/Chemical Sensors for Neurohormones Detection-A Review.ACS omega · 2022Review
- Nano gold-doped molecularly imprinted electrochemical sensor for rapid and ultrasensitive cortisol detection.Biosensors & bioelectronics · 2022Article
- Immunosensor for Assessing the Welfare of Trainee Guide Dogs.Biosensors · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We discovered that several types of steroid hormones quench the fluorescence of quantum dots (QDs) at close proximity. Inspired by the finding, we developed a new type of biosensor for the sensitive detection of cortisol via direct fluorescence quenching of functionalized QD probes directly induced by the capture of target cortisol without additional reporter reagents. The detection selectivity was provided by cortisol-selective aptamers or anticortisol antibodies conjugated on the QD surfaces. With the magnetic nanoparticle labeling, the new sensing method enabled rapid cortisol sensing at physiologically relevant concentrations and yielded the detection limit of ∼1 nM for aptamer-based sensors and ∼100 pM for antibody-based sensors. We also evaluated the new detection method using saliva samples with an optimized sample preparation process under the assistance of magnetic manipulation. The result showed a satisfying recovery rate for spiked saliva tests. The facile sensing technology offers an appealing approach for the detection of steroid hormones in point-of-care settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.