Evidence map›Paper›PMID 32545910›Full record

ArticleBioengineering (Basel, Switzerland)2020

Pseudopterosin and

Bailu Xie, Jan Hänsel, Vanessa Mundorf, Janina Betz, Irene Reimche, Mert Erkan, Ibrahim Büdeyri, Anne Gesell, Russell G Kerr, Ni Putu Ariantari and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Phenanthroindolizidine Alkaloids Isolated fromInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 5 countries.

Bailu XieDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
Jan HänselDepartment of Biomedical Sciences, Institute of Health Research and Education, University of Osnabrück, 49074 Osnabrück, Germany.ORCID 0000-0002-8696-1384
Vanessa MundorfTechnische Hochschule Köln, University of Technology, Arts and Sciences, 50678 Köln, Germany.
Janina BetzTechnische Hochschule Köln, University of Technology, Arts and Sciences, 50678 Köln, Germany.ORCID 0000-0001-5119-1351
Irene ReimcheDepartment of Biomedical Sciences, Institute of Health Research and Education, University of Osnabrück, 49074 Osnabrück, Germany.
Mert ErkanDepartment of Surgery, School of Medicine, Koç University, Sarıyer/İstanbul 34450, Turkey.
Ibrahim BüdeyriKoç University Research Center for Translational Medicine, 34450 Istanbul, Turkey.ORCID 0000-0002-4200-4566
Anne GesellMaterial and Chemical Characterization Facility, University of Bath, Bath BA2 7AY, UK.
Russell G KerrDepartment of Chemistry, and Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.
Ni Putu AriantariInstitute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Haiqian YuInstitute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Peter ProkschInstitute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Nicole TeuschDepartment of Biomedical Sciences, Institute of Health Research and Education, University of Osnabrück, 49074 Osnabrück, Germany.ORCID 0000-0002-9030-1493
Randall J MrsnyDepartment of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
TH Köln - University of Applied Sciences · DEUniversity of Bath · GBHeinrich Heine University Düsseldorf · DEKoç University · TROsnabrück University · DEUdayana University · IDUniversity of Prince Edward Island · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current therapies for treating pancreatic ductal adenocarcinoma (PDAC) are largely ineffective, with the desmoplastic environment established within these tumors being considered a central issue. We established a 3D spheroid co-culture in vitro model using a PDAC cell line (either PANC-1 or Capan-2), combined with stellate cells freshly isolated from pancreatic tumors (PSC) or hepatic lesions (HSC), and human type I collagen to analyze the efficiency of the chemotherapeutic gemcitabine (GEM) as well as two novel drug candidates derived from natural products: pseudopterosin (PsA-D) and

Indexed as

3D co-culturegemcitabineKi-67O-methyltylophorinidinep53pancreatic ductal adenocarcinomaPDACpseudopterosinspheroidstellate cellstumor microenvironment

Identifiers

PMID32545910
PMCPMC7357459
OpenAlexW3035054253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.