ArticleInternational journal of molecular sciences2020
An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- RNF126 writes a non-canonical ubiquitin code on midnolin to tune protein stability.Acta biochimica et biophysica Sinica · 2026Article
- Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity.Current issues in molecular biology · 2025Review
- TRIM25 ubiquitinates and degrades p62/SQSTM1 to suppress autophagy.Acta biochimica et biophysica Sinica · 2025Article
- Neuronal UBE3A substrates hold therapeutic potential for Angelman syndrome.Current opinion in neurobiology · 2024Review
- Non-proteolytic ubiquitination of HBx controls HBV replication.Virologica Sinica · 2024Article
- RNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liver hepatocellular carcinoma cells.Oncology letters · 2024Article
- The ubiquitin codes in cellular stress responses.Protein & cell · 2024Review
- UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.FEBS open bio · 2023Article
- The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation.Cell discovery · 2023Article
- Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy.International journal of molecular sciences · 2023Review
- AMBRA1 attenuates the proliferation of uveal melanoma cells.Open medicine (Warsaw, Poland) · 2022Article
- Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2.Open medicine (Warsaw, Poland) · 2022Article
- Ubiquitination of p21 by E3 Ligase TRIM21 Promotes the Proliferation of Human Neuroblastoma Cells.Neuromolecular medicine · 2021Article
- A novel mutation in NF1 gene of patient with Neurofibromatosis type 1: A case report and functional study.Molecular genetics & genomic medicine · 2021Article
- Loss of nuclear UBE3A activity is the predominant cause of Angelman syndrome in individuals carrying UBE3A missense mutations.Human molecular genetics · 2021Article
- Two loss-of-function ANKRD11 variants in Chinese patients with short stature and a possible molecular pathway.American journal of medical genetics. Part A · 2021Article
- Highly Specialized Ubiquitin-Like Modifications: Shedding Light into the UFM1 Enigma.Biomolecules · 2021Review
- Characterization of Two Loss-of-Function NF1 Variants in Chinese Patients and Potential Molecular Interpretations of Phenotypes.Frontiers in genetics · 2021Article
- A Novel Loss-of-FunctionFrontiers in genetics · 2021Article
- Demethylation ofOncology letters · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Global identification of substrates for PTMs (post-translational modifications) represents a critical but yet dauntingly challenging task in understanding biology and disease pathology. Here we presented a synthetic biology approach, namely 'YESS', which coupled Y2H (yeast two hybrid) interactome screening with PTMs reactions reconstituted in bacteria for substrates identification and validation, followed by the functional validation in mammalian cells. Specifically, the sequence-independent Gateway
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.