Evidence map›Paper›PMID 32545689›Full record

ArticleViruses2020

Treatment with Class A CpG Oligodeoxynucleotides in Cats with Naturally Occurring Feline Parvovirus Infection: A Prospective Study.

Filippo Ferri, Federico Porporato, Francesco Rossi, Daniela Enache, Carolina Callegari, Gabriele Gerardi, Luigi M Coppola, Barbara Contiero, Chiara Crinò, Neda Ranjbar Kohan and 4 more

Open access · goldAbstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Prophylactic Efficacy of Equine Immunoglobulin F(ab')Applied biochemistry and biotechnology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Filippo FerriAniCura Istituto Veterinario di Novara, Strada Provinciale 9, 28060 Granozzo con Monticello (NO), Italy.
Federico PorporatoAniCura Istituto Veterinario di Novara, Strada Provinciale 9, 28060 Granozzo con Monticello (NO), Italy.
Francesco RossiAniCura Istituto Veterinario di Novara, Strada Provinciale 9, 28060 Granozzo con Monticello (NO), Italy.
Daniela EnacheAniCura Istituto Veterinario di Novara, Strada Provinciale 9, 28060 Granozzo con Monticello (NO), Italy.
Carolina CallegariAniCura Istituto Veterinario di Novara, Strada Provinciale 9, 28060 Granozzo con Monticello (NO), Italy.
Gabriele GerardiDepartment of Animal Medicine, Production and Health, University of Padova, viale dell'Università 16, 35020 Legnaro (PD), Italy.
Luigi M CoppolaDepartment of Animal Medicine, Production and Health, University of Padova, viale dell'Università 16, 35020 Legnaro (PD), Italy.
Barbara ContieroDepartment of Animal Medicine, Production and Health, University of Padova, viale dell'Università 16, 35020 Legnaro (PD), Italy.ORCID 0000-0002-6586-5035
Chiara CrinòThe Ralph Veterinary Referral Centre, Fourth Avenue, Globe Business Park, Marlow SL7 1YG, UK.
Neda Ranjbar KohanClinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Marina L MeliClinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Hans LutzClinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Regina Hofmann-LehmannClinical Laboratory, Department of Clinical Diagnostics and Services, and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland.ORCID 0000-0001-9750-4296
Eric ZiniAniCura Istituto Veterinario di Novara, Strada Provinciale 9, 28060 Granozzo con Monticello (NO), Italy.
Stazione Sperimentale del Vetro · ITUniversity of Padua · ITUniversity of Zurich · CHWillows Veterinary Centre and Referral Service · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feline parvovirus (FPV) causes severe gastroenteritis and leukopenia in cats; the outcome is poor. Information regarding specific treatments is lacking. Class A CpG oligodeoxynucleotides (CpG-A) are short single-stranded DNAs, stimulating type I interferon production. In cats, CpG-A induced an antiviral response in vivo and inhibited FPV replication in vitro. The aim was to prospectively investigate the effects of CpG-A on survival, clinical score, hematological findings, antiviral response (cytokines), viremia, and fecal shedding (real-time qPCR) in cats naturally infected with FPV. Forty-two FPV-infected cats were randomized to receive 100 µg/kg of CpG-A (

Indexed as

AnimalsCatsCell CountFeline PanleukopeniaFeline Panleukopenia VirusFemaleLeukocytesMaleOligodeoxyribonucleotidesProspective StudiesCPG-oligonucleotideOligodeoxyribonucleotidesantiviralcatCpG-Afeline parvovirusMx proteintreatment

Identifiers

PMID32545689
PMCPMC7354499
OpenAlexW3034395991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.