ReviewBrain sciences2020
Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation.
Review in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- A Moderated Mediation Model Linking Speech-in-Noise Exposure, Speech Perception in Noise Ability, Loneliness, and Depression.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain.The Journal of comparative neurology · 2026Article
- Hearing Loss Is Associated With Depression and Dysthymia in the All of Us Research Program.The Laryngoscope · 2025Article
- Article
- The daily auditory environments of people with tinnitus.Scientific reports · 2025Article
- The Association Between Hearing Loss and Depression in a Large Electronic Health Record System.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Article
- From genomic discovery to application in age-related hearing loss: a global bibliometric and cross-ethnic analysis.Frontiers in aging neuroscience · 2025Article
- Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders.Nature and science of sleep · 2025Review
- Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2024Review
- Multiple talker processing in autistic adult listeners.Scientific reports · 2024Article
- Psychiatry and sensation: the epigenetic links.Epigenomics · 2024Review
- Electroconvulsive therapy modulates loudness dependence of auditory evoked potentials: a pilot MEG study.Frontiers in psychiatry · 2024Article
- Solitude and serotonin: juvenile isolation alters the covariation between social behavior and cFos expression by serotonergic neurons.Frontiers in neuroscience · 2024Article
- Effects of cochlear implantation on cognitive decline in older adults: A systematic review and meta-analysis.Heliyon · 2023Article
- Attraction of female house mice to male ultrasonic courtship vocalizations depends on their social experience and estrous stage.PloS one · 2023Article
- Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice.Frontiers in human neuroscience · 2023Article
- Hearing loss, depression, and cognition in younger and older adult CI candidates.Frontiers in neurology · 2023Article
- Hearing loss and depressive symptoms in older Chinese: whether social isolation plays a role.BMC geriatrics · 2022Article
- A sex-specific feedback projection from aromatase-expressing neurons in the medial amygdala to the accessory olfactory bulb.The Journal of comparative neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
For social animals that communicate acoustically, hearing loss and social isolation are factors that independently influence social behavior. In human subjects, hearing loss may also contribute to objective and subjective measures of social isolation. Although the behavioral relationship between hearing loss and social isolation is evident, there is little understanding of their interdependence at the level of neural systems. Separate lines of research have shown that social isolation and hearing loss independently target the serotonergic system in the rodent brain. These two factors affect both presynaptic and postsynaptic measures of serotonergic anatomy and function, highlighting the sensitivity of serotonergic pathways to both types of insult. The effects of deficits in both acoustic and social inputs are seen not only within the auditory system, but also in other brain regions, suggesting relatively extensive effects of these deficits on serotonergic regulatory systems. Serotonin plays a much-studied role in depression and anxiety, and may also influence several aspects of auditory cognition, including auditory attention and understanding speech in challenging listening conditions. These commonalities suggest that serotonergic pathways are worthy of further exploration as potential intervening mechanisms between the related conditions of hearing loss and social isolation, and the affective and cognitive dysfunctions that follow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.