Evidence map›Paper›PMID 32545454›Full record

ReviewCancers2020

Clinical Applications of Molecular Biomarkers in Prostate Cancer.

Felipe Couñago, Fernando López-Campos, Ana Aurora Díaz-Gavela, Elena Almagro, Esaú Fenández-Pascual, Iván Henríquez, Rebeca Lozano, Estefanía Linares Espinós, Alfonso Gómez-Iturriaga, Guillermo de Velasco and 7 more

Abstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Genetic variants ofInternational journal of medical sciences · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Prostate cancer in omics era.Cancer cell international · 2022
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Felipe CouñagoRadiation Oncology, Hospital Universitario Quirónsalud Madrid, 28223 Madrid, Spain.
Fernando López-CamposRadiation Oncology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Ana Aurora Díaz-GavelaRadiation Oncology, Hospital Universitario Quirónsalud Madrid, 28223 Madrid, Spain.
Elena AlmagroMedical Oncology, Hospital Universitario Quirónsalud Madrid, 28223 Madrid, Spain.
Esaú Fenández-PascualLyx Institute of Urology, Universidad Francisco de Vitoria, 28006 Madrid, Spain.
Iván HenríquezRadiation Oncology, Hospital Universitario Sant Joan, 43204 Reus, Spain.
Rebeca LozanoProstate Cancer Clinical Research Unit, Spanish National Cancer Research Centre, 28029 Madrid, Spain.
Estefanía Linares EspinósLyx Institute of Urology, Universidad Francisco de Vitoria, 28006 Madrid, Spain.
Alfonso Gómez-IturriagaCruces University Hospital, Biocruces Heath Research Institute, 48903 Barakaldo, Spain.
Guillermo de VelascoMedical Oncology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Luis Miguel Quintana FrancoDepartment of Urology, Hospital Universitario La Paz, 28046 Madrid, Spain.
Ignacio Rodríguez-MelcónRadiation Oncology, Hospital Universitario de Gran Canaria Dr. Negrín, 35010 Las Palmas de Gran Canaria, Spain.
José López-TorrecillaRadiation Oncology-ERESA, Hospital General Universitario de Valencia, 46014 Valencia, Spain.
Daniel E SprattDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Luis Leonardo GuerreroRadiation Oncology, Hospital Universitario Quirónsalud Madrid, 28223 Madrid, Spain.
Juan Ignacio Martínez-SalamancaLyx Institute of Urology, Universidad Francisco de Vitoria, 28006 Madrid, Spain.
Elia Del CerroRadiation Oncology, Hospital Universitario Quirónsalud Madrid, 28223 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is clinically relevant molecular heterogeneity in prostate cancer (PCa), but this biological diversity has had only a minimal impact on clinical practice. Treatment outcomes in patients with localised PCa are often highly variable, even among patients stratified to the same risk group or disease state based on standard clinical and pathological parameters. In recent years, the development of gene panels has provided valuable data on the differential expression of genes in patients with PCa. Nevertheless, there is an urgent need to identify and validate prognostic and predictive biomarkers that can be applied across clinical scenarios, ranging from localised disease to metastatic castration-resistant PCa. The availability of such tools would allow for precision medicine to finally reach PCa patients. In this review, we evaluate current data on molecular biomarkers for PCa, with an emphasis on the biomarkers and gene panels with the most robust evidence to support their application in routine clinical practice.

Indexed as

biomarkersDNA repairgene panelsgenetic testinggermline mutationprecision medicineprostate cancerprostate genomics

Identifiers

PMID32545454
PMCPMC7352850

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.