ArticleCancers2020
Epidemiology of Signet Ring Cell Adenocarcinomas.
Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study.The oncologist · 2022Pooled it
- Young-onset signet ring cell colorectal adenocarcinoma: demographics, clinicopathological profile, and survival analysis.Proceedings (Baylor University. Medical Center) · 2026Article
- Invasive poorly cohesive carcinoma with focal signet ring cell features arising from intracholecystic papillary neoplasm in the gallbladder.Clinical journal of gastroenterology · 2026Article
- Distinct genomic landscape of colorectal signet ring cell carcinoma reveals frequent KMT2 family alterations and SMAD4 inactivation.BMC cancer · 2026Article
- Survivability in patients with rare sigmoid colon adenocarcinoma variants: exploring the influence of rural-urban continuum codes and social determinants of health in the USA.Cancer causes & control : CCC · 2026Article
- A case report of diffuse large B-cell lymphoma and gastric signet ring cell adenocarcinoma in the same anatomic site: a clinical and management conundrum.Journal of gastrointestinal oncology · 2026Article
- ARID1A loss drives gastric signet ring cell carcinoma by regulating mucin production and secretion.Nature communications · 2026Article
- Popliteal fossa metastasis from rectal carcinoma in a young adult: A rare case report.Radiology case reports · 2026Article
- Construction and testing of a nomogram for patients with pancreatic signet-ring cell carcinoma and analysis of treatment-related survival differences: a study based on the Surveillance, Epidemiology, and End Results (SEER) database.Translational cancer research · 2026Article
- A distinct form of colorectal cancer: signet ring cell carcinoma.Translational cancer research · 2026Article
- Urachal Signet Ring Cell Carcinoma: A Clinicopathological Analysis of 28 Cases.Current oncology (Toronto, Ont.) · 2026Article
- Cutaneous metastasis of signet ring cell carcinoma.JAAD case reports · 2026Article
- Predicting lymph node metastasis in colorectal cancer using case-level multiple instance learning.World journal of gastroenterology · 2026Article
- The Changing Landscape of Hereditary Diffuse Gastric Cancer.Journal of gastric cancer · 2026Review
- Uncommon Presentation of Primary Bladder Signet Ring Cell Carcinoma With Peritoneal Carcinomatosis: A Rare Case Report.Case reports in urology · 2026Article
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- Primary bladder signet ring cell adenocarcinoma in a young male with Lynch Syndrome.Urology case reports · 2025Article
- Primary signet ring cell carcinoma of the appendix presenting as gangrenous appendicitis with peritonitis: a case report.Annals of medicine and surgery (2012) · 2025Article
- Imaging features of appendiceal signet ring cell carcinoma with uterine implantation: A case report.World journal of radiology · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signet ring cell adenocarcinomas (SRCCs) are a rare histological subtype of adenocarcinomas with a poor prognosis, typically due to advanced disease at diagnosis. A signet ring cell, mimicking its moniker, contains abundant intracytoplasmic mucin that pushes the nucleus to the periphery. In these cancers, this cell feature comprises more than 50% of the tumor. Despite predilection for the gastrointestinal tract, and in particular the stomach, primary SRCCs are also described in other sites, typically in case reports. This literature, however, lacks a standardized overview of the SRCC disease entity. Using a retrospective cohort approach, we summarize the clinicodemographic and mortality outcomes of SRCCs in thirteen primary sites, comprising 95% of all SRCCs in the Surveillance, Epidemiology, and End Results Program (SEER), a population-level cancer database covering nearly one-third of the United States population. SRCCs general trends compared to matching nonvariant adenocarcinomas are earlier age of onset, with initial presentation favoring higher rates of regional or distant disease presentation and poor tumor differentiation. After multivariable analysis, SRCCs typically have worse overall survivals, but substantial variances exist depending on tumor location. Identifying SRCCs at earlier disease stages is likely the single most important intervention to improving outcomes for these patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.